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Apical–basal polarity and the control of epithelial form and function
CE Buckley, D St Johnston - Nature reviews Molecular cell biology, 2022 - nature.com
Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …
The LKB1–AMPK pathway: metabolism and growth control in tumour suppression
DB Shackelford, RJ Shaw - Nature Reviews Cancer, 2009 - nature.com
In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …
Organization and execution of the epithelial polarity programme
Epithelial cells require apical–basal plasma membrane polarity to carry out crucial vectorial
transport functions and cytoplasmic polarity to generate different cell progenies for tissue …
transport functions and cytoplasmic polarity to generate different cell progenies for tissue …
Cadherins and cancer: how does cadherin dysfunction promote tumor progression?
It has long been recognized that the cell–cell adhesion receptor, E-cadherin, is an important
determinant of tumor progression, serving as a suppressor of invasion and metastasis in …
determinant of tumor progression, serving as a suppressor of invasion and metastasis in …
Epithelial cell polarity, stem cells and cancer
After years of extensive scientific discovery much has been learned about the networks that
regulate epithelial homeostasis. Loss of expression or functional activity of cell adhesion …
regulate epithelial homeostasis. Loss of expression or functional activity of cell adhesion …
Tight junctions and cell polarity
K Shin, VC Fogg, B Margolis - Annu. Rev. Cell Dev. Biol., 2006 - annualreviews.org
The tight junction is an intracellular junctional structure that mediates adhesion between
epithelial cells and is required for epithelial cell function. Tight junctions control paracellular …
epithelial cells and is required for epithelial cell function. Tight junctions control paracellular …
[HTML][HTML] The PAR proteins: fundamental players in animal cell polarization
The par genes were discovered in genetic screens for regulators of cytoplasmic partitioning
in the early embryo of C. elegans, and encode six different proteins required for asymmetric …
in the early embryo of C. elegans, and encode six different proteins required for asymmetric …
Cortical flows powered by asymmetrical contraction transport PAR proteins to establish and maintain anterior-posterior polarity in the early C. elegans embryo
E Munro, J Nance, JR Priess - Developmental cell, 2004 - cell.com
The C. elegans PAR proteins PAR-3, PAR-6, and PKC-3 are asymmetrically localized and
have essential roles in cell polarity. We show that the one-cell C. elegans embryo contains a …
have essential roles in cell polarity. We show that the one-cell C. elegans embryo contains a …
The PAR-aPKC system: lessons in polarity
Ten years ago, par-1 and par-3 were cloned as two of the six par genes essential for the
asymmetric division of the Caenorhabditis elegans zygote. PAR-1 is a protein kinase …
asymmetric division of the Caenorhabditis elegans zygote. PAR-1 is a protein kinase …
Cell polarity in eggs and epithelia: parallels and diversity
Cell polarity, the generation of cellular asymmetries, is necessary for diverse processes in
animal cells, such as cell migration, asymmetric cell division, epithelial barrier function, and …
animal cells, such as cell migration, asymmetric cell division, epithelial barrier function, and …