Apical–basal polarity and the control of epithelial form and function

CE Buckley, D St Johnston - Nature reviews Molecular cell biology, 2022 - nature.com
Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …

The LKB1–AMPK pathway: metabolism and growth control in tumour suppression

DB Shackelford, RJ Shaw - Nature Reviews Cancer, 2009 - nature.com
In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …

Organization and execution of the epithelial polarity programme

E Rodriguez-Boulan, IG Macara - Nature reviews Molecular cell biology, 2014 - nature.com
Epithelial cells require apical–basal plasma membrane polarity to carry out crucial vectorial
transport functions and cytoplasmic polarity to generate different cell progenies for tissue …

Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

A Jeanes, CJ Gottardi, AS Yap - Oncogene, 2008 - nature.com
It has long been recognized that the cell–cell adhesion receptor, E-cadherin, is an important
determinant of tumor progression, serving as a suppressor of invasion and metastasis in …

Epithelial cell polarity, stem cells and cancer

F Martin-Belmonte, M Perez-Moreno - Nature Reviews Cancer, 2012 - nature.com
After years of extensive scientific discovery much has been learned about the networks that
regulate epithelial homeostasis. Loss of expression or functional activity of cell adhesion …

Tight junctions and cell polarity

K Shin, VC Fogg, B Margolis - Annu. Rev. Cell Dev. Biol., 2006 - annualreviews.org
The tight junction is an intracellular junctional structure that mediates adhesion between
epithelial cells and is required for epithelial cell function. Tight junctions control paracellular …

[HTML][HTML] The PAR proteins: fundamental players in animal cell polarization

B Goldstein, IG Macara - Developmental cell, 2007 - cell.com
The par genes were discovered in genetic screens for regulators of cytoplasmic partitioning
in the early embryo of C. elegans, and encode six different proteins required for asymmetric …

Cortical flows powered by asymmetrical contraction transport PAR proteins to establish and maintain anterior-posterior polarity in the early C. elegans embryo

E Munro, J Nance, JR Priess - Developmental cell, 2004 - cell.com
The C. elegans PAR proteins PAR-3, PAR-6, and PKC-3 are asymmetrically localized and
have essential roles in cell polarity. We show that the one-cell C. elegans embryo contains a …

The PAR-aPKC system: lessons in polarity

A Suzuki, S Ohno - Journal of cell science, 2006 - journals.biologists.com
Ten years ago, par-1 and par-3 were cloned as two of the six par genes essential for the
asymmetric division of the Caenorhabditis elegans zygote. PAR-1 is a protein kinase …

Cell polarity in eggs and epithelia: parallels and diversity

D St Johnston, J Ahringer - Cell, 2010 - cell.com
Cell polarity, the generation of cellular asymmetries, is necessary for diverse processes in
animal cells, such as cell migration, asymmetric cell division, epithelial barrier function, and …