Lineage plasticity in cancer: a shared pathway of therapeutic resistance
Lineage plasticity, the ability of cells to transition from one committed developmental
pathway to another, has been proposed as a source of intratumoural heterogeneity and of …
pathway to another, has been proposed as a source of intratumoural heterogeneity and of …
Targeting signaling pathways in prostate cancer: mechanisms and clinical trials
Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …
genomic landscapes and biological functions, the treatment of PCa continues to improve …
ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer
Abstract Treatment with androgen receptor pathway inhibitors (ARPIs) in prostate cancer
leads to the emergence of resistant tumors characterized by lineage plasticity and …
leads to the emergence of resistant tumors characterized by lineage plasticity and …
Mitochondrial dysfunction-targeted nanosystems for precise tumor therapeutics
Mitochondria play critical roles in the regulation of the proliferation and apoptosis of
cancerous cells. Targeted induction of mitochondrial dysfunction in cancer cells by …
cancerous cells. Targeted induction of mitochondrial dysfunction in cancer cells by …
Cellular and molecular mechanisms underlying prostate cancer development: therapeutic implications
Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …
CBP/p300: critical co-activators for nuclear steroid hormone receptors and emerging therapeutic targets in prostate and breast cancers
Simple Summary The CREB-binding protein (CBP) and p300 are paralogous lysine
acetyltransferases that serve as critical co-activators for transcription factors involved in …
acetyltransferases that serve as critical co-activators for transcription factors involved in …
The Expression of Proto-Oncogene ETS-Related Gene (ERG) Plays a Central Role in the Oncogenic Mechanism Involved in the Development and Progression of …
The ETS-related gene (ERG) is proto-oncogene that is classified as a member of the ETS
transcription factor family, which has been found to be consistently overexpressed in about …
transcription factor family, which has been found to be consistently overexpressed in about …
The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer
CULLIN3‐based E3 ubiquitin ligase substrate‐binding adaptor gene SPOP is frequently
mutated in prostate cancer (PCa). PCa harboring SPOP hotspot mutants (eg, F133V) are …
mutated in prostate cancer (PCa). PCa harboring SPOP hotspot mutants (eg, F133V) are …
Molecular mechanisms and genetic alterations in prostate cancer: From diagnosis to targeted therapy
F Fontana, M Anselmi, P Limonta - Cancer Letters, 2022 - Elsevier
Prostate cancer remains one of the most lethal malignancies among men worldwide.
Although the primary tumor can be successfully managed by surgery and radiotherapy …
Although the primary tumor can be successfully managed by surgery and radiotherapy …
Association between SARS-CoV-2 infection and disease severity among prostate cancer patients on androgen deprivation therapy: a systematic review and meta …
Purpose Androgen-regulated enzymes such as the angiotensin-converting enzyme 2
(ACE2) and the transmembrane serine protease 2 (TMPRSS2) are involved in the SARS …
(ACE2) and the transmembrane serine protease 2 (TMPRSS2) are involved in the SARS …