Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases

M Lin, N Liu, Z Qin, Y Wang - Acta Pharmacologica Sinica, 2022 - nature.com
Both mitochondrial dysfunction and neuroinflammation are implicated in neurodegeneration
and neurodegenerative diseases. Accumulating evidence shows multiple links between …

Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation

P Norat, S Soldozy, JD Sokolowski, CM Gorick… - NPJ Regenerative …, 2020 - nature.com
Mitochondria are fundamental for metabolic homeostasis in all multicellular eukaryotes. In
the nervous system, mitochondria-generated adenosine triphosphate (ATP) is required to …

Going the extra (synaptic) mile: excitotoxicity as the road toward neurodegenerative diseases

A Armada-Moreira, JI Gomes, CC Pina… - Frontiers in cellular …, 2020 - frontiersin.org
Excitotoxicity is a phenomenon that describes the toxic actions of excitatory
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …

The role of mitochondria in inflammation: from cancer to neurodegenerative disorders

S Missiroli, I Genovese, M Perrone, B Vezzani… - Journal of clinical …, 2020 - mdpi.com
The main features that are commonly attributed to mitochondria consist of the regulation of
cell proliferation, ATP generation, cell death and metabolism. However, recent scientific …

α‐synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson's disease

HY Tu, BS Yuan, XO Hou, XJ Zhang, CS Pei, YT Ma… - Aging cell, 2021 - Wiley Online Library
The cell‐to‐cell transfer of α‐synuclein (α‐Syn) greatly contributes to Parkinson's disease
(PD) pathogenesis and underlies the spread of α‐Syn pathology. During this process …

Effects of curcumin on mitochondria in neurodegenerative diseases

H Bagheri, F Ghasemi, GE Barreto, R Rafiee… - Biofactors, 2020 - Wiley Online Library
Neurodegenerative diseases (NDs) result from progressive deterioration of selectively
susceptible neuron populations in different central nervous system (CNS) regions. NDs are …

Alzheimer's disease: Molecular aspects and treatment opportunities using herbal drugs

S Thakral, A Yadav, V Singh, M Kumar, P Kumar… - Ageing Research …, 2023 - Elsevier
Abstract Alzheimer's disease (AD), also called senile dementia, is the most common
neurological disorder. Around 50 million people, mostly of advanced age, are suffering from …

Mitochondria and brain disease: a comprehensive review of pathological mechanisms and therapeutic opportunities

VJ Clemente-Suárez, L Redondo-Flórez… - Biomedicines, 2023 - mdpi.com
Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …

On the neuroprotective effects of naringenin: pharmacological targets, signaling pathways, molecular mechanisms, and clinical perspective

Z Nouri, S Fakhri, FF El-Senduny, N Sanadgol… - Biomolecules, 2019 - mdpi.com
As a group of progressive, chronic, and disabling disorders, neurodegenerative diseases
(NDs) affect millions of people worldwide, and are on the rise. NDs are known as the …

Unraveling the link between mitochondrial dynamics and neuroinflammation

LG de Oliveira, YS Angelo, AH Iglesias… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammatory and neurodegenerative diseases are a major public health problem
worldwide, especially with the increase of life-expectancy observed during the last decades …