Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases
M Lin, N Liu, Z Qin, Y Wang - Acta Pharmacologica Sinica, 2022 - nature.com
Both mitochondrial dysfunction and neuroinflammation are implicated in neurodegeneration
and neurodegenerative diseases. Accumulating evidence shows multiple links between …
and neurodegenerative diseases. Accumulating evidence shows multiple links between …
Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation
Mitochondria are fundamental for metabolic homeostasis in all multicellular eukaryotes. In
the nervous system, mitochondria-generated adenosine triphosphate (ATP) is required to …
the nervous system, mitochondria-generated adenosine triphosphate (ATP) is required to …
Going the extra (synaptic) mile: excitotoxicity as the road toward neurodegenerative diseases
A Armada-Moreira, JI Gomes, CC Pina… - Frontiers in cellular …, 2020 - frontiersin.org
Excitotoxicity is a phenomenon that describes the toxic actions of excitatory
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …
The role of mitochondria in inflammation: from cancer to neurodegenerative disorders
The main features that are commonly attributed to mitochondria consist of the regulation of
cell proliferation, ATP generation, cell death and metabolism. However, recent scientific …
cell proliferation, ATP generation, cell death and metabolism. However, recent scientific …
α‐synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson's disease
HY Tu, BS Yuan, XO Hou, XJ Zhang, CS Pei, YT Ma… - Aging cell, 2021 - Wiley Online Library
The cell‐to‐cell transfer of α‐synuclein (α‐Syn) greatly contributes to Parkinson's disease
(PD) pathogenesis and underlies the spread of α‐Syn pathology. During this process …
(PD) pathogenesis and underlies the spread of α‐Syn pathology. During this process …
Effects of curcumin on mitochondria in neurodegenerative diseases
Neurodegenerative diseases (NDs) result from progressive deterioration of selectively
susceptible neuron populations in different central nervous system (CNS) regions. NDs are …
susceptible neuron populations in different central nervous system (CNS) regions. NDs are …
Alzheimer's disease: Molecular aspects and treatment opportunities using herbal drugs
Abstract Alzheimer's disease (AD), also called senile dementia, is the most common
neurological disorder. Around 50 million people, mostly of advanced age, are suffering from …
neurological disorder. Around 50 million people, mostly of advanced age, are suffering from …
Mitochondria and brain disease: a comprehensive review of pathological mechanisms and therapeutic opportunities
VJ Clemente-Suárez, L Redondo-Flórez… - Biomedicines, 2023 - mdpi.com
Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …
On the neuroprotective effects of naringenin: pharmacological targets, signaling pathways, molecular mechanisms, and clinical perspective
As a group of progressive, chronic, and disabling disorders, neurodegenerative diseases
(NDs) affect millions of people worldwide, and are on the rise. NDs are known as the …
(NDs) affect millions of people worldwide, and are on the rise. NDs are known as the …
Unraveling the link between mitochondrial dynamics and neuroinflammation
Neuroinflammatory and neurodegenerative diseases are a major public health problem
worldwide, especially with the increase of life-expectancy observed during the last decades …
worldwide, especially with the increase of life-expectancy observed during the last decades …