Advancing cell-based cancer immunotherapy through stem cell engineering
Advances in cell-based therapy, particularly CAR-T cell therapy, have transformed the
treatment of hematological malignancies. Although an important step forward for the field …
treatment of hematological malignancies. Although an important step forward for the field …
CRISPR-Cas-mediated transcriptional modulation: The therapeutic promises of CRISPRa and CRISPRi
L Bendixen, TI Jensen, RO Bak - Molecular Therapy, 2023 - cell.com
The CRISPR-Cas system is commonly known for its ability to cleave DNA in a
programmable manner, which has democratized gene editing and facilitated recent …
programmable manner, which has democratized gene editing and facilitated recent …
Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones
Ferroptosis, a cell death process driven by iron-dependent phospholipid peroxidation, has
been implicated in various diseases. There are two major surveillance mechanisms to …
been implicated in various diseases. There are two major surveillance mechanisms to …
[HTML][HTML] Massively parallel base editing to map variant effects in human hematopoiesis
Systematic evaluation of the impact of genetic variants is critical for the study and treatment
of human physiology and disease. While specific mutations can be introduced by genome …
of human physiology and disease. While specific mutations can be introduced by genome …
The extracellular matrix integrates mitochondrial homeostasis
Cellular homeostasis is intricately influenced by stimuli from the microenvironment, including
signaling molecules, metabolites, and pathogens. Functioning as a signaling hub within the …
signaling molecules, metabolites, and pathogens. Functioning as a signaling hub within the …
Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection
Host: pathogen interactions dictate the outcome of infection, yet the limitations of current
approaches leave large regions of this interface unexplored. Here, we develop a novel …
approaches leave large regions of this interface unexplored. Here, we develop a novel …
[HTML][HTML] Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia
CS Park, H Yoshihara, Q Gao, C Qu, I Iacobucci… - Cell reports, 2023 - cell.com
The bone marrow microenvironment (BME) drives drug resistance in acute lymphoblastic
leukemia (ALL) through leukemic cell interactions with bone marrow (BM) niches, but the …
leukemia (ALL) through leukemic cell interactions with bone marrow (BM) niches, but the …
The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice
Obesity is a chronic disease that contributes to the development of insulin resistance, type 2
diabetes (T2D), and cardiovascular risk. Glucose-dependent insulinotropic polypeptide …
diabetes (T2D), and cardiovascular risk. Glucose-dependent insulinotropic polypeptide …
LINE1 and PRC2 control nucleolar organization and repression of the 8C state in human ESCs
The mechanisms that ensure developmental progression in the early human embryo remain
largely unknown. Here, we show that the family of long interspersed nuclear element 1 …
largely unknown. Here, we show that the family of long interspersed nuclear element 1 …
Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
Small cell lung cancers (SCLCs) are composed of heterogeneous subtypes marked by
lineage-specific transcription factors, including ASCL1, NEUROD1, and POU2F3. POU2F3 …
lineage-specific transcription factors, including ASCL1, NEUROD1, and POU2F3. POU2F3 …