The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …

Cytoplasmic lipid droplets are important organelles in nearly every eukaryotic and some
prokaryotic cells. Storing and providing energy is their main function, but they do not work in …

Macroautophagy/autophagy is an evolutionarily highly conserved catabolic process that is
important for the clearance of cytosolic contents to maintain cellular homeostasis and …

After having been disregarded for a long time as inert fat drops, lipid droplets (LDs) are now
recognized as ubiquitous cellular organelles with key functions in lipid biology and beyond …

The conserved VPS13 proteins constitute a new family of lipid transporters at membrane
contact sites. These large proteins are suspected to bridge membranes and form a direct …

The Endoplasmic Reticulum (ER) is an endomembrane system that plays a multiplicity of
roles in cell physiology and populates even the most distal cell compartments, including …

There is currently no accepted classification of autosomal recessive cerebellar ataxias, a
group of disorders characterized by important genetic heterogeneity and complex …

Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

Autophagy is a major degradative pathway that plays a key role in sustaining cell
homeostasis, integrity, and physiological functions. Macroautophagy, which ensures the …