The physical association between the endoplasmic reticulum (ER) and mitochondria, which
is known as the mitochondria-associated ER membrane (MAM), has important roles in …

Desmin is a muscle-specific type III intermediate filament essential for proper muscular
structure and function. In human, mutations affecting desmin expression or promoting its …

Cardiac-restricted overexpression of the Ca2+-binding protein S100A1 has been shown to
lead to increased myocardial contractile performance in vitro and in vivo. Since decreased …

S100A1, a small homodimeric EF-hand Ca2+-binding protein (~ 21 kDa), plays an important
regulatory role in Ca2+ signaling pathways involved in various biological functions including …

Background—The incidence of heart failure is ever-growing, and it is urgent to develop
improved treatments. An attractive approach is gene therapy; however, the clinical barrier …

The S100 proteins are exclusively expressed in vertebrates and are the largest subgroup
within the superfamily of EF-hand Ca 2+-binding proteins Generally, S100 proteins are …

With increasing knowledge of basic molecular mechanisms governing the development of
heart failure (HF), the possibility of specifically targeting key pathological players is evolving …

S100A1, a Ca 2+-sensing protein of the EF-hand family, is most highly expressed in
myocardial tissue, and cardiac S100A1 overexpression in vitro has been shown to enhance …

S100A1, a Ca2+-sensing protein of the EF-hand family that is expressed predominantly in
cardiac muscle, plays a pivotal role in cardiac contractility in vitro and in vivo. It has recently …

S100A1 is a member of the S100 family of calcium-binding proteins. As with most S100
proteins, S100A1 undergoes a large conformational change upon binding calcium as …