Diagnostics and therapies have shown evident advances. Tumour surgery, chemotherapy
and radiotherapy are the main techniques in treat cancers. Targeted therapy and drug …

Abstract Src homology 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2), encoded
by PTPN11, regulates cell proliferation, differentiation, apoptosis and survival via releasing …

Src homology 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2), encoded by the
human PTPN11 gene, is a ubiquitously expressed protein tyrosine phosphatase (PTP) that …

The docking proteins of the Grb-associated binder (Gab) family transduce cellular signals
between receptors and intracellular downstream effectors, and provide a platform for protein …

FLT3-ITD is the most frequent tyrosine kinase mutation in acute myeloid leukemia (AML)
associated with poor prognosis. We previously found that FLT3-ITD activates the …

A major goal in signaling biology is the establishment of high-throughput quantitative
methods for measuring changes in protein phosphorylation of entire signal transduction …

Ribosomal S6 kinase (RSK) family is a group of serine/threonine kinases, including four
isoforms (RSK1/2/3/4). As a downstream effector of the Ras-mitogen-activated protein …

Role of Shp2: The dysregulation of cell signaling cascades associated with the cell
differentiation and growth, due to the deletion, insertion or point mutation in specific amino …

Signaling via extracellular regulated kinase 1/2 (ERK1/2) and p90 ribosomal S6 kinase
(RSK), a downstream effector, mediates numerous processes. For example, ERK1/2-RSK …

Prostate cancer has a proclivity to metastasize to bone. The mechanism by which prostate
cancer cells are able to survive and progress in the bone microenvironment is not clear …