Peptidomics

R Hellinger, A Sigurdsson, W Wu… - Nature Reviews …, 2023 - nature.com
Peptides are biopolymers, typically consisting of 2–50 amino acids. They are biologically
produced by the cellular ribosomal machinery or by non-ribosomal enzymes and …

Advances in mass spectrometry imaging for spatial cancer metabolomics

X Ma, FM Fernández - Mass spectrometry reviews, 2024 - Wiley Online Library
Mass spectrometry (MS) has become a central technique in cancer research. The ability to
analyze various types of biomolecules in complex biological matrices makes it well suited for …

Advances in MALDI mass spectrometry imaging single cell and tissues

X Zhu, T Xu, C Peng, S Wu - Frontiers in Chemistry, 2022 - frontiersin.org
Compared with conventional optical microscopy techniques, mass spectrometry imaging
(MSI) or imaging mass spectrometry (IMS) is a powerful, label-free analytical technique …

Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research

JL Norris, RM Caprioli - Chemical reviews, 2013 - ACS Publications
Human beings are adept at discerning relevant information from complex systems by
processing visual information. Similarly, as scientists labor to understand the fundamental …

High spatial resolution imaging of biological tissues using nanospray desorption electrospray ionization mass spectrometry

R Yin, KE Burnum-Johnson, X Sun, SK Dey, J Laskin - Nature Protocols, 2019 - nature.com
Mass spectrometry imaging (MSI) enables label-free spatial map** of hundreds of
biomolecules in tissue sections. This capability provides valuable information on tissue …

Metabolic imaging at the single-cell scale: recent advances in mass spectrometry imaging

IS Gilmore, S Heiles, CL Pieterse - Annual review of analytical …, 2019 - annualreviews.org
There is an increasing appreciation that every cell, even of the same type, is different. This
complexity, when additionally combined with the variety of different cell types in tissue, is …

MALDI matrices for low molecular weight compounds: an endless story?

CD Calvano, A Monopoli, TRI Cataldi… - Analytical and …, 2018 - Springer
Since its introduction in the 1980s, matrix-assisted laser desorption/ionization mass
spectrometry (MALDI MS) has gained a prominent role in the analysis of high molecular …

Mass spectrometry imaging for plant biology: a review

BA Boughton, D Thinagaran, D Sarabia, A Bacic… - Phytochemistry …, 2016 - Springer
Mass spectrometry imaging (MSI) is a develo** technique to measure the spatio-temporal
distribution of many biomolecules in tissues. Over the preceding decade, MSI has been …

Mass spectrometric imaging for biomedical tissue analysis

K Chughtai, RMA Heeren - Chemical reviews, 2010 - ACS Publications
A mass spectrometer is described as the smallest weighing scale ever used in the world. 1
Mass spectrometry (MS) is a unique technique that has an interdisciplinary nature, which …

Imaging mass spectrometry

LA McDonnell, RMA Heeren - Mass spectrometry reviews, 2007 - Wiley Online Library
Imaging mass spectrometry combines the chemical specificity and parallel detection of mass
spectrometry with microscopic imaging capabilities. The ability to simultaneously obtain …