Designing drug delivery systems for cell therapy

LLW Wang, Y Gao, Z Feng, DJ Mooney… - Nature Reviews …, 2024 - nature.com
Cell therapies, such as immune cell and stem cell therapies, are being preclinically and
clinically explored for the treatment of various diseases, but are often limited by low efficacy …

Neutrophils bearing adhesive polymer micropatches as a drug-free cancer immunotherapy

N Kumbhojkar, S Prakash, T Fukuta… - Nature Biomedical …, 2024 - nature.com
Tumour-associated neutrophils can exert antitumour effects but can also assume a pro-
tumoural phenotype in the immunosuppressive tumour microenvironment. Here we show …

Nano/genetically engineered cells for immunotherapy

J Shen, Y Zhou, L Yin - BMEMat, 2024 - Wiley Online Library
Immunotherapy has recently emerged as a promising therapeutic modality for the treatment
of various diseases such as cancer, inflammation, autoimmune diseases, and infectious …

Mechanoimmune-Driven Backpack Sustains Dendritic Cell Maturation for Synergistic Tumor Radiotherapy

H Yu, Z Liu, H Guo, X Hu, Y Wang, X Cheng… - ACS …, 2024 - ACS Publications
Cell backpacks present significant potential in both therapeutic and diagnostic applications,
making it essential to further explore their interactions with host cells. Current evidence …

Polymer Micropatches as B-Cell Engagers

S Prakash, N Kumbhojkar, AP Gottlieb… - … Applied Materials & …, 2024 - ACS Publications
B cells, despite their several unique functionalities, remain largely untapped for use as an
adoptive cell therapy and are limited to in vitro use for antibody production. B cells can be …

Dynamic monitoring soft tissue healing via visualized Gd-crosslinked double network MRI microspheres

T Chen, Z Cai, X Zhao, G Wei, H Wang, T Bo… - Journal of …, 2024 - Springer
By integrating magnetic resonance-visible components with scaffold materials, hydrogel
microspheres (HMs) become visible under magnetic resonance imaging (MRI), allowing for …

Engineering translational vaccine delivery systems with the polyphenol tannic acid

ME Janes - 2024 - dspace.mit.edu
Supramolecular biomaterials, which are capable of spontaneous assembly via diverse non-
covalent interactions, represent an exciting frontier in drug delivery due to their ease of …