Cortisol, a critical glucocorticoid hormone produced by the adrenal glands, plays a pivotal
role in various physiological processes. Its release is finely orchestrated by the …

Blood vessel endothelial cells (ECs) have long been known to modulate inflammation by
regulating immune cell trafficking, activation status and function. However, whether the …

Microglia are emerging as critical regulators of neuronal function and behavior in nearly
every area of neuroscience. Initial reports focused on classical immune functions of …

Crosstalk between gut and brain has long been appreciated in health and disease, and the
gut microbiota is a key player in communication between these two distant organs. Yet, the …

The incidence of depression and anxiety is amplified by obesity. Mounting evidence reveals
that the psychiatric consequences of obesity stem from poor diet, inactivity, and visceral …

Stress resilience is the phenomenon that some people maintain their mental health despite
exposure to adversity or show only temporary impairments followed by quick recovery …

Stress-linked psychiatric disorders, including anxiety and major depressive disorder, are
associated with systemic inflammation. Recent studies have reported stress-induced …

Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …

Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

Psychosocial stress has profound effects on the body, including the immune system and the
brain,. Although a large number of pre-clinical and clinical studies have linked peripheral …