R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …

The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes.
The exosome has a central role in several aspects of RNA biogenesis, including RNA …

Whole-genome sequencing of longitudinal tumor pairs representing transformation of
follicular lymphoma to high-grade B cell lymphoma with MYC and BCL2 rearrangements …

Much of the mammalian genome is transcribed, generating long non-coding RNAs
(lncRNAs) that can undergo post-transcriptional surveillance whereby only a subset of the …

In order to promote an efficient humoral immune response, germinal center B cells modify
both the antigen recognition and effector domains by programmed genetic alterations of …

Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype
switching by deaminating deoxycytidines within immunoglobulin genes, leading to somatic …

We have ablated the cellular RNA degradation machinery in differentiated B cells and
pluripotent embryonic stem cells (ESCs) by conditional mutagenesis of core (Exosc3) and …

The eukaryotic RNA exosome is an essential and conserved protein complex that can
degrade or process RNA substrates in the 3′-to-5′ direction. Since its discovery nearly …

The initiation, progression, and relapse of cancers often result from mutations occurring
within somatic cells. Consequently, processes that elevate mutation rates accelerate …

Class switch recombination (CSR) at the immunoglobulin heavy-chain (IgH) locus is
associated with the formation of R-loop structures over switch (S) regions. While these often …