Air− liquid interface (ALI) culture models currently represent a valid instrument to recreate
the typical aspects of the respiratory tract in vitro in both healthy and diseased state. They …

Background Flavonoids are naturally occurring compounds, extensively distributed in plants.
T helper (Th) 1 and Th2 cytokines balance plays an essential role in the reaction of …

To investigate the effect of eupatilin in asthma treatment, we evaluated its therapeutic effect
and related signal transduction in OVA-induced asthmatic mice and LPS-stimulated …

Background Respiratory diseases pose a grave threat to human life. Therefore,
understanding their pathogenesis and therapeutic strategy is important. Ferroptosis is a …

Despite the large number of drugs available for the treatment of asthma, in 5–10% of the
patients this disease is not well controlled. While most treatments palliate symptoms, those …

Introduction: The pulmonary inflammatory response results from exposure to injurious
factors and is associated with oxidative stress, which intensifies the pathological reaction. In …

Ethnopharmacology relevance Baicalin, a flavonoid compound, was isolated from traditional
Chinese medicine Scutellaria baicalensis Georgi. The study aimed to explore the regulatory …

Sirtuins are NAD-dependent class III histone deacetylase, which modulate the epigenetic
changes to influence the functions in normal and diseased conditions. Preclinical studies …

Background Observational and mechanistic data suggest a role for vitamin D in childhood
asthma. However, subsequent interventional trials have been inconsistent. We aimed to …

Ethnopharmacological relevance Taraxasterol was isolated from the Chinese medicinal
herb Taraxacum officinale which has been frequently used as a remedy for inflammatory …