Estrogen and glycemic homeostasis: the fundamental role of nuclear estrogen receptors ESR1/ESR2 in glucose transporter GLUT4 regulation

KCR Gregorio, CP Laurindo, UF Machado - Cells, 2021‏ - mdpi.com
Impaired circulating estrogen levels have been related to impaired glycemic homeostasis
and diabetes mellitus (DM), both in females and males. However, for the last twenty years …

MicroRNAs‐mediated regulation of skeletal muscle GLUT4 expression and translocation in insulin resistance

JV Esteves, FJ Enguita… - Journal of diabetes …, 2017‏ - Wiley Online Library
The solute carrier family 2 facilitated glucose transporter member 4 (GLUT4) plays a key role
in the insulin‐induced glucose uptake by muscle and adipose tissues. In prediabetes and …

Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle

L Al-Khalili, K Bouzakri, S Glund… - Molecular …, 2006‏ - academic.oup.com
We identified signaling pathways by which IL-6 regulates skeletal muscle differentiation and
metabolism. Primary human skeletal muscle cells were exposed to IL-6 (25 ng/ml either …

Human muscle gene expression following resistance exercise and blood flow restriction

MJ Drummond, S Fujita, ABE Takashi… - … and science in …, 2008‏ - pmc.ncbi.nlm.nih.gov
INTRODUCTION Blood flow restriction in combination with low-intensity resistance exercise
(REFR) increases skeletal muscle size to a similar extent as compared to traditional high …

Estrogen receptors: new players in diabetes mellitus

RPA Barros, UF Machado, JÅ Gustafsson - Trends in molecular medicine, 2006‏ - cell.com
Diabetes mellitus type 2 is a systemic disease characterized by imbalance of energy
metabolism, which is mainly caused by inadequate insulin action. Recent data have …

Advanced glycation end products-induced insulin resistance involves repression of skeletal muscle GLUT4 expression

DC Pinto-Junior, KS Silva, ML Michalani… - Scientific Reports, 2018‏ - nature.com
Little is known about advanced glycation end products (AGEs) participation in glucose
homeostasis, a process in which skeletal muscle glucose transporter GLUT4 (Scl2a4 gene) …

[HTML][HTML] AGEs-induced and endoplasmic reticulum stress/inflammation-mediated regulation of GLUT4 expression and atherogenesis in diabetes mellitus

M Passarelli, UF Machado - Cells, 2021‏ - mdpi.com
In recent decades, complex and exquisite pathways involved in the endoplasmic reticulum
(ER) and inflammatory stress responses have been demonstrated to participate in the …

Transcriptional regulation of the insulin-responsive glucose transporter GLUT4 gene: from physiology to pathology

E Karnieli, M Armoni - American Journal of Physiology …, 2008‏ - journals.physiology.org
The insulin-responsive glucose transporter 4 (GLUT4) plays a key role in glucose uptake
and metabolism in insulin target tissues. Being a rate-limiting step in glucose metabolism …

Temporal response of angiogenesis and hypertrophy to resistance training in young men.

TM Holloway, T Snijders, VANL LJC… - Medicine and science …, 2018‏ - europepmc.org
Methods In this double-blind, randomized control trial, 36 men (22±1 yr) were randomized to
placebo or protein supplementation, and participated in 12 wk of resistance training …

[HTML][HTML] Quercetin decreases inflammatory response and increases insulin action in skeletal muscle of ob/ob mice and in L6 myotubes

GF Anhê, MM Okamoto, A Kinote, C Sollon… - European journal of …, 2012‏ - Elsevier
Quercetin is a potent anti-inflammatory flavonoid, but its capacity to modulate insulin
sensitivity in obese insulin resistant conditions is unknown. This study investigated the effect …