Somatostatin (SST) and somatostatin receptors (SSTRs) play an important role in the brain
and gastrointestinal (GI) system. SST is produced in various organs and cells, and the …

Hypoglycemia is the result of defects/impairment in glucose homeostasis. The main
etiological causes are metabolic and/or endocrine and/or other congenital disorders …

Background: Hyperinsulinism (HI) due to dysregulation of pancreatic beta-cell insulin
secretion is the most common and most severe cause of persistent hypoglycemia in infants …

Congenital hyperinsulinism (CHI) is a condition characterised by severe and recurrent
hypoglycaemia in infants and young children caused by inappropriate insulin over …

Hyperinsulinaemic hypoglycaemia (HH) is the most common cause of persistent
hypoglycaemia in infants and children with incidence estimated at 1 per 50,000 live births …

With the increasing global incidence of diabetes mellitus, physicians may encounter more
patients with acute and chronic complications of medication-induced hyperglycemia and …

Pancreatic neuroendocrine tumors, or pNETs, represent a rare and clinically heterogenous
subset of pancreatic neoplasms. One such pNET, the insulinoma, is found to be malignant in …

Over the last several decades peptide drug discovery has been a source of significant
challenge, innovation, and achievement against varying target classes. Noteworthy …

Aim Nutritional measures often suffice for managing high‐output ileostomy (HOI) in
paediatric patients, but pharmacological treatment may be required to control ostomy output …

We present the case of a 36-year-old female who was diagnosed at birth with CHI that
caused severe hypoglycaemia unresponsive to Diazoxide. Subtotal pancreatectomy was …