Optogenetics for light control of biological systems
Optogenetic techniques have been developed to allow control over the activity of selected
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …
Restoring vision to the blind with chemical photoswitches
Degenerative retinal diseases such as retinitis pigmentosa (RP) and age-related macular
degeneration (AMD) affect millions of people around the world and lead to irreversible vision …
degeneration (AMD) affect millions of people around the world and lead to irreversible vision …
Light-induced charge generation in polymeric nanoparticles restores vision in advanced-stage retinitis pigmentosa rats
Retinal dystrophies such as Retinitis pigmentosa are among the most prevalent causes of
inherited legal blindness, for which treatments are in demand. Retinal prostheses have been …
inherited legal blindness, for which treatments are in demand. Retinal prostheses have been …
[HTML][HTML] Optogenetics for visual restoration: from proof of principle to translational challenges
Degenerative retinal disorders are a diverse family of diseases commonly leading to
irreversible photoreceptor death, while leaving the inner retina relatively intact. Over recent …
irreversible photoreceptor death, while leaving the inner retina relatively intact. Over recent …
[HTML][HTML] Unsupervised spike sorting for large-scale, high-density multielectrode arrays
We present a method for automated spike sorting for recordings with high-density, large-
scale multielectrode arrays. Exploiting the dense sampling of single neurons by multiple …
scale multielectrode arrays. Exploiting the dense sampling of single neurons by multiple …
Vascular pericyte impairment and connexin43 gap junction deficit contribute to vasomotor decline in diabetic retinopathy
E Ivanova, T Kovacs-Oller… - Journal of …, 2017 - Soc Neuroscience
Adequate blood flow is essential to brain function, and its disruption is an early indicator in
diseases, such as stroke and diabetes. However, the mechanisms contributing to this …
diseases, such as stroke and diabetes. However, the mechanisms contributing to this …
Transplanted pluripotent stem cell-derived photoreceptor precursors elicit conventional and unusual light responses in mice with advanced retinal degeneration
Retinal dystrophies often lead to blindness. Develo** therapeutic interventions to restore
vision is therefore of paramount importance. Here we demonstrate the ability of pluripotent …
vision is therefore of paramount importance. Here we demonstrate the ability of pluripotent …
Retinoic acid inhibitors mitigate vision loss in a mouse model of retinal degeneration
Rod and cone photoreceptors degenerate in retinitis pigmentosa (RP). While downstream
neurons survive, they undergo physiological changes, including accelerated spontaneous …
neurons survive, they undergo physiological changes, including accelerated spontaneous …
Retinoic acid induces hyperactivity, and blocking its receptor unmasks light responses and augments vision in retinal degeneration
Light responses are initiated in photoreceptors, processed by interneurons, and synaptically
transmitted to retinal ganglion cells (RGCs), which send information to the brain. Retinitis …
transmitted to retinal ganglion cells (RGCs), which send information to the brain. Retinitis …
A head mounted device stimulator for optogenetic retinal prosthesis
Objective. Our main objective is to demonstrate that compact high radiance gallium nitride
displays can be used with conventional virtual reality optics to stimulate an optogenetic …
displays can be used with conventional virtual reality optics to stimulate an optogenetic …