Connexins in cardiovascular and neurovascular health and disease: pharmacological implications
Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …
hemichannels and as intercellular gap junction channels that directly connect cells. In the …
Astrocytes as guardians of neuronal excitability: mechanisms underlying epileptogenesis
QP Verhoog, L Holtman, E Aronica… - Frontiers in …, 2020 - frontiersin.org
Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …
Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles
C Giaume, L Leybaert, C C. Naus… - Frontiers in …, 2013 - frontiersin.org
Functional interaction between neurons and glia is an exciting field that has expanded
tremendously during the past decade. Such partnership has multiple impacts on neuronal …
tremendously during the past decade. Such partnership has multiple impacts on neuronal …
Potential of naturally derived alkaloids as multi-targeted therapeutic agents for neurodegenerative diseases
Alkaloids are a class of secondary metabolites that can be derived from plants, fungi and
marine sponges. They are widely known as a continuous source of medicine for the …
marine sponges. They are widely known as a continuous source of medicine for the …
Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer's disease
In Alzheimer's disease (AD), astrocyte properties are modified but their involvement in this
pathology is only beginning to be appreciated. The expression of connexins, proteins …
pathology is only beginning to be appreciated. The expression of connexins, proteins …
The inflammasome pathway is amplified and perpetuated in an autocrine manner through connexin43 hemichannel mediated ATP release
Background Connexin43 hemichannels have been implicated in many inflammatory
diseases including diabetic retinopathy (DR). Particularly, hemichannel-mediated ATP …
diseases including diabetic retinopathy (DR). Particularly, hemichannel-mediated ATP …
Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective …
ES Vizi, M Kisfali, T Lőrincz - Brain research bulletin, 2013 - Elsevier
In acute ischaemic brain injury and chronic neurodegeneration, the primary step leading to
excitotoxicity and cell death is the excessive and/or prolonged activation of glutamate (Glu) …
excitotoxicity and cell death is the excessive and/or prolonged activation of glutamate (Glu) …
Inflammasome activation induces pyroptosis in the retina exposed to ocular hypertension injury
Mechanical stress and hypoxia during episodes of ocular hypertension (OHT) trigger glial
activation and neuroinflammation in the retina. Glial activation and release of pro …
activation and neuroinflammation in the retina. Glial activation and release of pro …
Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease
Gap junctions are unique membrane channels that play a significant role in intercellular
communication in the develo** and mature central nervous system (CNS). These …
communication in the develo** and mature central nervous system (CNS). These …
Gap junctions and connexins in microglia-related oxidative stress and neuroinflammation: perspectives for drug discovery
Microglia represent the immune system of the brain. Their role is central in two phenomena,
neuroinflammation and oxidative stress, which are at the roots of different pathologies …
neuroinflammation and oxidative stress, which are at the roots of different pathologies …