The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …

Protein kinase C (PKC) has been a tantalizing target for drug discovery ever since it was first
identified as the receptor for the tumour promoter phorbol ester in 1982. Although initial …

Protein kinase C (PKC) isoforms comprise a family of lipid-activated enzymes that have
been implicated in a wide range of cellular functions. PKCs are modular enzymes comprised …

Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of
the most extensively studied signaling kinases. PKCs signal through multiple pathways and …

The discovery in the early 1980s that protein kinase C is 'the receptor'for the tumor-
promoting phorbol esters catapulted this enzyme to the forefront of research in signal …

Janmey, Paul A. The Cytoskeleton and Cell Signaling: Component Localization and
Mechanical Coupling. Physiol. Rev. 78: 763–781, 1998.—The three-dimensional …

Vascular smooth muscle (VSM) plays an important role in the regulation of vascular function.
Identifying the mechanisms of VSM contraction has been a major research goal in order to …

Certain pathogenic species of Bacillus and Clostridium have developed unique methods for
intoxicating cells that employ the classic enzymatic “AB” paradigm for protein toxins. The …

Protein kinase C has been in the spotlight since the discovery two decades ago that is
activated by the lipid second messenger diacylglycerol. Despite protein kinase C's enduring …

Protein kinase C (PKC), a family of related serine‐threonine kinases, is a key player in the
cellular responses mediated by the second messenger diacylglycerol (DAG) and the …