Aquaporins: important but elusive drug targets

AS Verkman, MO Anderson… - Nature reviews Drug …, 2014 - nature.com
The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water
transport across the plasma membranes of cells in response to osmotic gradients. Data from …

Chloroplast function and ion regulation in plants growing on saline soils: lessons from halophytes

J Bose, R Munns, S Shabala, M Gilliham… - Journal of …, 2017 - academic.oup.com
Salt stress impacts multiple aspects of plant metabolism and physiology. For instance it
inhibits photosynthesis through stomatal limitation, causes excessive accumulation of …

Plant aquaporins: membrane channels with multiple integrated functions

C Maurel, L Verdoucq, DT Luu… - Annu. Rev. Plant Biol., 2008 - annualreviews.org
Aquaporins are channel proteins present in the plasma and intracellular membranes of plant
cells, where they facilitate the transport of water and/or small neutral solutes (urea, boric …

Ammonia production, excretion, toxicity, and defense in fish: a review

YK Ip, SF Chew - Frontiers in physiology, 2010 - frontiersin.org
Many fishes are ammonotelic but some species can detoxify ammonia to glutamine or urea.
Certain fish species can accumulate high levels of ammonia in the brain or defense against …

Ectomycorrhizas and water relations of trees: a review

T Lehto, JJ Zwiazek - Mycorrhiza, 2011 - Springer
There is plenty of evidence for improved nutrient acquisition by ectomycorrhizas in trees;
however, their role in water uptake is much less clear. In addition to experiments showing …

Plant aquaporins: roles in plant physiology

G Li, V Santoni, C Maurel - Biochimica et Biophysica Acta (BBA)-General …, 2014 - Elsevier
Background Aquaporins are membrane channels that facilitate the transport of water and
small neutral molecules across biological membranes of most living organisms. Scope of …

Ammonia toxicity to the brain

O Braissant, VA McLin, C Cudalbu - Journal of inherited metabolic disease, 2013 - Springer
Hyperammonemia can be caused by various acquired or inherited disorders such as urea
cycle defects. The brain is much more susceptible to the deleterious effects of ammonium in …

Multiple functions of the crustacean gill: osmotic/ionic regulation, acid-base balance, ammonia excretion, and bioaccumulation of toxic metals

RP Henry, Č Lucu, H Onken, D Weihrauch - Frontiers in physiology, 2012 - frontiersin.org
The crustacean gill is a multi-functional organ, and it is the site of a number of physiological
processes, including ion transport, which is the basis for hemolymph osmoregulation; acid …

Ammonium stress in Arabidopsis: signaling, genetic loci, and physiological targets

B Li, G Li, HJ Kronzucker, F Baluška, W Shi - Trends in plant science, 2014 - cell.com
Ammonium (NH 4+) toxicity is a significant ecological and agricultural issue, and an
important phenomenon in cell biology. As a result of increasing soil nitrogen input and …

Non‐selective cation channel activity of aquaporin AtPIP2;1 regulated by Ca2+ and pH

CS Byrt, M Zhao, M Kourghi, J Bose… - Plant, cell & …, 2017 - Wiley Online Library
The aquaporin AtPIP2; 1 is an abundant plasma membrane intrinsic protein in Arabidopsis
thaliana that is implicated in stomatal closure, and is highly expressed in plasma …