Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the slee**
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …

Melatonin is a ubiquitous molecule present in almost every live being from bacteria to
humans. In vertebrates, besides being produced in peripheral tissues and acting as an …

Sleep disorders are a group of conditions that affect the ability to sleep well on a regular
basis and cause significant impairments in social and occupational functions. Although …

Abstract Although the GABAergic benzodiazepines (BZDs) and Z-drugs (zolpidem,
zopiclone, and zaleplon) are FDA-approved for insomnia disorders with a strong evidence …

Melatonin receptors are seven transmembrane‐spanning proteins belonging to the GPCR
superfamily. In mammals, two melatonin receptor subtypes exist‐MT1 and MT2‐encoded by …

Melatonin, or 5-methoxy-N-acetyltryptamine, is synthesized and released by the pineal
gland and locally in the retina following a circadian rhythm, with low levels during the day …

Transdermal drug delivery is of vital importance for medical treatments. However, user
adherence to long-term repetitive drug delivery poses a grand challenge. Furthermore, the …

Melatonin, through its different receptors, has pleiotropic functions in mammalian brain.
Melatonin is secreted mainly by the pineal gland and exerts its effects via receptor-mediated …

Melatonin is an ancient molecule that is evident in high concentrations in various tissues
throughout the body. It can be separated into two pools; one of which is synthesized by the …

The pathophysiological function of the G-protein coupled melatonin MT1 and MT2 receptors
has not yet been well-clarified. Recent advancements using selective MT1/MT2 receptor …