Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments
R Ruze, T Liu, X Zou, J Song, Y Chen, R Xu… - Frontiers in …, 2023 - frontiersin.org
The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …
[HTML][HTML] Gut microbiome and health: mechanistic insights
The gut microbiota is now considered as one of the key elements contributing to the
regulation of host health. Virtually all our body sites are colonised by microbes suggesting …
regulation of host health. Virtually all our body sites are colonised by microbes suggesting …
[HTML][HTML] Chronic inflammation in the etiology of disease across the life span
Although intermittent increases in inflammation are critical for survival during physical injury
and infection, recent research has revealed that certain social, environmental and lifestyle …
and infection, recent research has revealed that certain social, environmental and lifestyle …
The gut microbiota (microbiome) in cardiovascular disease and its therapeutic regulation
In the last two decades, considerable interest has been shown in understanding the
development of the gut microbiota and its internal and external effects on the intestine, as …
development of the gut microbiota and its internal and external effects on the intestine, as …
Immunosenescence and its hallmarks: how to oppose aging strategically? A review of potential options for therapeutic intervention
Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …
Obesity and cancer risk: Emerging biological mechanisms and perspectives
Continuously rising trends in obesity-related malignancies render this disease spectrum a
public health priority. Worldwide, the burden of cancer attributable to obesity, expressed as …
public health priority. Worldwide, the burden of cancer attributable to obesity, expressed as …
Smart and bioinspired systems for overcoming biological barriers and enhancing disease theranostics
Nanomedicine has emerged as a promising mean to improve theranostic efficacy and
reduce side effects. Currently, only very small percentage of injected dose reaches the solid …
reduce side effects. Currently, only very small percentage of injected dose reaches the solid …
Mitochondrial uncoupling: a key controller of biological processes in physiology and diseases
S Demine, P Renard, T Arnould - Cells, 2019 - mdpi.com
Mitochondrial uncoupling can be defined as a dissociation between mitochondrial
membrane potential generation and its use for mitochondria-dependent ATP synthesis …
membrane potential generation and its use for mitochondria-dependent ATP synthesis …
Phage-guided modulation of the gut microbiota of mouse models of colorectal cancer augments their responses to chemotherapy
DW Zheng, X Dong, P Pan, KW Chen, JX Fan… - Nature biomedical …, 2019 - nature.com
The microbiota in the human gut is strongly correlated with the progression of colorectal
cancer (CRC) and with therapeutic responses to CRC. Here, by leveraging the higher …
cancer (CRC) and with therapeutic responses to CRC. Here, by leveraging the higher …
Phlorizin ameliorates obesity-associated endotoxemia and insulin resistance in high-fat diet-fed mice by targeting the gut microbiota and intestinal barrier integrity
XY Zhang, J Chen, K Yi, L Peng, J **e, X Gou… - Gut …, 2020 - Taylor & Francis
Phlorizin (PHZ) is one of phytonutrients in apples that contributes to the health-promoting
effect implicated by the saying,'an apple a day keeps the doctor away'. PHZ was firstly …
effect implicated by the saying,'an apple a day keeps the doctor away'. PHZ was firstly …