The investigation of the hypothalamicpituitary-adrenal (HPA) axis in chronic inflammation
has demonstrated: 1) an anti-inflammatory influence of the HPA axis; 2) low serum levels of …

6 indolo [2, 3-a] carbazole (1) 1H-indolo [2, 3-a] pyrrolo [3, 4-c] carbazole (2) Since the
synthetic approaches to indolo [2, 3-a] carbazoles were reviewed in volume 1 of this series …

We previously reported that nobiletin (5, 6, 7, 8, 3′, 4′-hexamethoxy flavone), a citrus
polymethoxy flavonoid, effectively interferes with the production of promatrix …

Neutral matrix metalloproteinases (MMPs) are responsible for the pathological features of
rheumatoid arthritis (RA) such as degradation of cartilage. We herein show the up-regulation …

Matrix metalloproteinases (MMPs) play a role in tissue remodelling and angiogenesis. We
have investigated the expression and regulation of MMP-1 (interstitial collagenase), MMP-2 …

The action of three matrix metalloproteinases (MMPs), 72-and 95-kDa gelatinases (MMP-2
and MMP-9) and PUMP (MMP-7), and a cysteine proteinase, cathepsin B, were investigated …

Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of inflammatory
disorders of the central nervous system (CNS) whereas the contribution of the major …

Stromelysin is a member of the family of metalloproteinases that degrade extracellular
matrix. In situ hybridisation and histopathological studies suggest that stromelysin activity …

Type II collagen is one of the predominant extracellular matrix macromolecules in cartilage
responsible for maintenance of integrity of this specialized tissue. We showed previously …

A chronic inflammatory disease may be characterized by an accumulation of activated
leukocytes at the site of inflammation. Since the chemokine RANTES may play an active role …