Methods and applications of in silico aptamer design and modeling
AA Buglak, AV Samokhvalov, AV Zherdev… - International journal of …, 2020 - mdpi.com
Aptamers are nucleic acid analogues of antibodies with high affinity to different targets, such
as cells, viruses, proteins, inorganic materials, and coenzymes. Empirical approaches allow …
as cells, viruses, proteins, inorganic materials, and coenzymes. Empirical approaches allow …
Computational tools for aptamer identification and optimization
D Sun, M Sun, J Zhang, X Lin, Y Zhang, F Lin… - TrAC Trends in …, 2022 - Elsevier
Aptamers are single-stranded DNA or RNA oligonucleotides that can selectively bind to a
specific target. They are generally obtained by SELEX, but the procedure is challenging and …
specific target. They are generally obtained by SELEX, but the procedure is challenging and …
Systematic evaluation of error rates and causes in short samples in next-generation sequencing
F Pfeiffer, C Gröber, M Blank, K Händler, M Beyer… - Scientific reports, 2018 - nature.com
Next-generation sequencing (NGS) is the method of choice when large numbers of
sequences have to be obtained. While the technique is widely applied, varying error rates …
sequences have to be obtained. While the technique is widely applied, varying error rates …
Design and prediction of aptamers assisted by in silico methods
SJ Lee, J Cho, BH Lee, D Hwang, JW Park - Biomedicines, 2023 - mdpi.com
An aptamer is a single-stranded DNA or RNA that binds to a specific target with high binding
affinity. Aptamers are developed through the process of systematic evolution of ligands by …
affinity. Aptamers are developed through the process of systematic evolution of ligands by …
Implementation of high-throughput sequencing (HTS) in aptamer selection technology
N Komarova, D Barkova, A Kuznetsov - International journal of molecular …, 2020 - mdpi.com
Aptamers are nucleic acid ligands that bind specifically to a target of interest. Aptamers have
gained in popularity due to their high potential for different applications in analysis …
gained in popularity due to their high potential for different applications in analysis …
AptaSUITE: a full-featured bioinformatics framework for the comprehensive analysis of aptamers from HT-SELEX experiments
The capability of producing and efficiently processing big data has revolutionized virtually
every field of science and technology and has enabled the analysis of experimental results …
every field of science and technology and has enabled the analysis of experimental results …
Highly Constrained Bicyclic Scaffolds for the Discovery of Protease-Stable Peptides via mRNA Display
Highly constrained peptides such as the knotted peptide natural products are promising
medicinal agents because of their impressive biostability and potent activity. Yet, libraries of …
medicinal agents because of their impressive biostability and potent activity. Yet, libraries of …
Aptamers as an approach to targeted cancer therapy
Conventional cancer treatments can cause serious side effects because they are not specific
to cancer cells and can damage healthy cells. Aptamers often are single-stranded …
to cancer cells and can damage healthy cells. Aptamers often are single-stranded …
A 2′ FY-RNA motif defines an aptamer for Ebolavirus secreted protein
With properties such as stability to long-term storage and amenability to repetitive use,
nucleic acid aptamers are compatible with many sensing/transducing platforms intended for …
nucleic acid aptamers are compatible with many sensing/transducing platforms intended for …
High-throughput and computational techniques for aptamer design
RK Kar - Expert Opinion on Drug Discovery, 2024 - Taylor & Francis
Introduction Aptamers refer to short ssDNA/RNA sequences that target small molecules,
proteins, or cells. Aptamers have significantly advanced diagnostic applications, including …
proteins, or cells. Aptamers have significantly advanced diagnostic applications, including …