In complex organisms, cells are often dependent on their extracellular matrix (ECM) for
structural integrity, the mechanical properties of tissues, and for signaled regulation of …

The extracellular matrix (ECM) is a network of biological macromolecules that surrounds
cells within tissues. In addition to serving as a physical support, the ECM actively influences …

Penetrating microscale microelectrodes made from flexible polymers tend to bend or deflect
and may fail to reach their target location. The development of flexible neural probes …

Manipulating an incorporated scaffold to direct cell behaviors play a key role in tissue
engineering. In this study, we developed novel nano-topographic oxidized silicon …

We explore textural cues as a mechanism for controlling neuronal process outgrowth in
primary cultures of mammalian neurons. The work uses a form of decal transfer lithography …

Effective intracellular transport of proteins and organelles is critical in cells and is especially
important for ensuring proper neuron functionality. In neurons, most proteins are synthesized …

Growing experimental evidence suggests that mechanical tension plays a significant role in
determining the growth, guidance, and function of neurons. Mechanical tension in axons …

Glycosaminoglycans (GAGs) are a family of diverse biomolecules that decorate
proteoglycans in the glycocalyx and extracellular matrix of all cells. They exist as linear …

The advancement and amalgamation of material science with biotechnology has resulted in
the development of advanced materials that have greatly improved biocompatibility. Surface …

Electrophysiological activities of neuronal networks can be recorded on microelectrode
arrays (MEAs). This technique requires tight coupling between MEA–surfaces and cells …