Targeting the latent reservoir for HIV-1
S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
[HTML][HTML] Focus: Infectious diseases: Mechanisms of virologic control and clinical characteristics of HIV+ elite/viremic controllers
E Gonzalo-Gil, U Ikediobi, RE Sutton - The Yale journal of biology …, 2017 - ncbi.nlm.nih.gov
Human immunodeficiency virus type 1 (HIV-1) disease is pandemic, with approximately 36
million infected individuals world-wide. For the vast majority of these individuals, untreated …
million infected individuals world-wide. For the vast majority of these individuals, untreated …
Advances in develo** CAR T-cell therapy for HIV cure
J Qi, C Ding, X Jiang, Y Gao - Frontiers in Immunology, 2020 - frontiersin.org
Acquired immune deficiency syndrome (AIDS), which is caused by HIV infection, is an
epidemic disease that has killed millions of people in the last several decades. Although …
epidemic disease that has killed millions of people in the last several decades. Although …
CCR5 revisited: how mechanisms of HIV entry govern AIDS pathogenesis
A Brelot, LA Chakrabarti - Journal of Molecular Biology, 2018 - Elsevier
The chemokine receptor CCR5 has been the focus of intensive studies since its role as a
coreceptor for HIV entry was discovered in 1996. These studies lead to the development of …
coreceptor for HIV entry was discovered in 1996. These studies lead to the development of …
Childhood trauma, the stress response and metabolic syndrome: a focus on DNA methylation
Childhood trauma (CT) is well established as a potent risk factor for the development of
mental disorders. However, the potential of adverse early experiences to exert chronic and …
mental disorders. However, the potential of adverse early experiences to exert chronic and …
Regulatory Noncoding and Predicted Pathogenic Coding Variants of CCR5 Predispose to Severe COVID-19
Genome-wide association studies (GWAS) found locus 3p21. 31 associated with severe
COVID-19. CCR5 resides at the same locus and, given its known biological role in other …
COVID-19. CCR5 resides at the same locus and, given its known biological role in other …
Identification of HIV infection-related DNA methylation sites and advanced epigenetic aging in HIV-positive, treatment-naive US veterans
Objective: HIV-positive individuals are at higher risk than healthy persons for aging-related
diseases, including myocardial infarction and non-AIDS defining cancers. Recent evidence …
diseases, including myocardial infarction and non-AIDS defining cancers. Recent evidence …
Chemokine receptor gene polymorphisms and COVID-19: Could knowledge gained from HIV/AIDS be important?
RK Mehlotra - Infection, Genetics and Evolution, 2020 - Elsevier
Emerging results indicate that an uncontrolled host immune response, leading to a life-
threatening condition called cytokine release syndrome (also termed “cytokine storm”), is the …
threatening condition called cytokine release syndrome (also termed “cytokine storm”), is the …
MiRNA-103 downmodulates CCR5 expression reducing human immunodeficiency virus type-1 entry and impacting latency establishment in CD4+ T cells
Activated-to-memory transitioning CD4+ T cells display elevated expression of the HIV-1 co-
receptor CCR5 and are more prone to HIV-1 latent infection. Here, we show that p53 …
receptor CCR5 and are more prone to HIV-1 latent infection. Here, we show that p53 …
The emerging role of epigenetics in the immune response to vaccination and infection: a systematic review
Extensive research has highlighted the role of infection-induced epigenetic events in the
development of cancer. More recently, attention has focused on the ability of non …
development of cancer. More recently, attention has focused on the ability of non …