State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson's disease
In the later stages of Parkinson's disease (PD), patients often manifest levodopa-induced
dyskinesia (LID), compromising their quality of life. The pathophysiology underlying LID is …
dyskinesia (LID), compromising their quality of life. The pathophysiology underlying LID is …
Technical and biological sources of noise confound multiplexed enhancer AAV screening
AC Hunker, JK Mich, N Taskin, A Torkelson, T Pham… - bioRxiv, 2025 - biorxiv.org
Cis-acting regulatory enhancer elements are valuable tools for gaining cell type-specific
genetic access. Leveraging large chromatin accessibility atlases, putative enhancer …
genetic access. Leveraging large chromatin accessibility atlases, putative enhancer …