Sequence-specific DNA binding Pyrrole–imidazole polyamides and their applications
Y Kawamoto, T Bando, H Sugiyama - Bioorganic & medicinal chemistry, 2018 - Elsevier
Abstract Pyrrole–imidazole polyamides (Py–Im polyamides) are cell-permeable compounds
that bind to the minor groove of double-stranded DNA in a sequence-specific manner …
that bind to the minor groove of double-stranded DNA in a sequence-specific manner …
Nature-inspired design of smart biomaterials using the chemical biology of nucleic acids
In the natural cellular environment, nucleic acid biomolecules like DNA have biological
implications via structural modifications and through precise coordination with other …
implications via structural modifications and through precise coordination with other …
Therapeutic gene regulation using pyrrole–imidazole polyamides
Recent innovations in cutting-edge sequencing platforms have allowed the rapid
identification of genes associated with communicable, noncommunicable and rare diseases …
identification of genes associated with communicable, noncommunicable and rare diseases …
Biomimetic artificial epigenetic code for targeted acetylation of histones
J Taniguchi, Y Feng, GN Pandian… - Journal of the …, 2018 - ACS Publications
While the central role of locus-specific acetylation of histone proteins in eukaryotic gene
expression is well established, the availability of designer tools to regulate acetylation at …
expression is well established, the availability of designer tools to regulate acetylation at …
Antiproliferative and apoptotic activities of sequence-specific histone acetyltransferase inhibitors
In parallel to monomeric epigenetic regulators, sequence-specific epigenetic regulators
represent versatile synthetic dual-target ligands that achieve regulatory control over multi …
represent versatile synthetic dual-target ligands that achieve regulatory control over multi …
Chemical control system of epigenetics
Epigenetics represents the inheritable changes to the chemical control system governing the
gene expression with no ensuing changes to the underlying DNA sequence. Environment …
gene expression with no ensuing changes to the underlying DNA sequence. Environment …
Nucleosomes and epigenetics from a chemical perspective
Nucleosomes, which are the fundamental building blocks of chromatin, are highly dynamic,
they play vital roles in the formation of higher‐order chromatin structures and orchestrate …
they play vital roles in the formation of higher‐order chromatin structures and orchestrate …
Pyrrole–Imidazole Polyamides–A Frontrunner in Nucleic Acid‐Based Small Molecule Drugs
The remarkable success of messenger RNA vaccines against the ongoing coronavirus‐
2019 (COVID‐19) pandemic renews attention toward nucleic acid therapeutics. While …
2019 (COVID‐19) pandemic renews attention toward nucleic acid therapeutics. While …
A Multi‐target Small Molecule for Targeted Transcriptional Activation of Therapeutically Significant Nervous System Genes
Y Wei, GN Pandian, T Zou, J Taniguchi, S Sato… - …, 2016 - Wiley Online Library
An integrated multi‐target small molecule capable of altering dynamic epigenetic and
transcription programs associated with the brain and nervous system has versatile …
transcription programs associated with the brain and nervous system has versatile …
Comparative Analysis of DNA‐Binding Selectivity of Hairpin and Cyclic Pyrrole‐Imidazole Polyamides Based on Next‐Generation Sequencing
Many long pyrrole‐imidazole polyamides (PIPs) have been synthesized in the search for
higher specificity, with the aim of realizing the great potential of such compounds in …
higher specificity, with the aim of realizing the great potential of such compounds in …