[HTML][HTML] Targeting PCSK9 to tackle cardiovascular disease
Lowering blood cholesterol levels efficiently reduces the risk of develo** atherosclerotic
cardiovascular disease (ASCVD), including coronary artery disease (CAD), which is the …
cardiovascular disease (ASCVD), including coronary artery disease (CAD), which is the …
Regulation of glucose and lipid metabolism in health and disease
Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the
most abundant sterol in mammals, is a key component of cell membranes although it does …
most abundant sterol in mammals, is a key component of cell membranes although it does …
PCSK9: from basic science discoveries to clinical trials
Unknown 15 years ago, PCSK9 (proprotein convertase subtilisin/kexin type 9) is now
common parlance among scientists and clinicians interested in prevention and treatment of …
common parlance among scientists and clinicians interested in prevention and treatment of …
PCSK9: a key modulator of cardiovascular health
Since the discovery of proprotein convertase subtilisin kexin 9 (PCSK9) in 2003, this PC has
attracted a lot of attention from the scientific community and pharmaceutical companies …
attracted a lot of attention from the scientific community and pharmaceutical companies …
Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion
INTRODUCTION The circadian clock is a molecular oscillator that coordinates behavior and
physiology in anticipation of the daily light cycle. Desynchrony of circadian cycles, through …
physiology in anticipation of the daily light cycle. Desynchrony of circadian cycles, through …
[HTML][HTML] Proprotein convertase subtilisin/kexin type 9: a view beyond the canonical cholesterol-lowering impact
C Macchi, N Ferri, CR Sirtori, A Corsini… - The American journal of …, 2021 - Elsevier
Proprotein convertase subtilisin/kexin type 9 (PCSK9), mainly synthetized and released by
the liver, represents one of the key regulators of low-density lipoprotein cholesterol …
the liver, represents one of the key regulators of low-density lipoprotein cholesterol …
COPII‐mediated trafficking at the ER/ERGIC interface
Coat proteins play multiple roles in the life cycle of a membrane‐bound transport
intermediate, functioning in lipid bilayer remodeling, cargo selection and targeting to an …
intermediate, functioning in lipid bilayer remodeling, cargo selection and targeting to an …
Manganese regulation of COPII condensation controls circulating lipid homeostasis
Precise control of circulating lipids is instrumental in health and disease. Bulk lipids, carried
by specialized lipoproteins, are secreted into the circulation, initially via the coat protein …
by specialized lipoproteins, are secreted into the circulation, initially via the coat protein …
Regulation of PCSK9 expression and function: mechanisms and therapeutic implications
X **a, Z Peng, H Gu, M Wang, G Wang… - Frontiers in …, 2021 - frontiersin.org
Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes degradation of low-density
lipoprotein receptor (LDLR) and plays a central role in regulating plasma levels of LDL …
lipoprotein receptor (LDLR) and plays a central role in regulating plasma levels of LDL …
The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion
Circulating PCSK9 destines low-density lipoprotein receptor for degradation in lysosomes,
resulting in increased LDL cholesterol. Accordingly, it is an attractive drug target for …
resulting in increased LDL cholesterol. Accordingly, it is an attractive drug target for …