Pharmaceutical aspects of intranasal delivery of vaccines using particulate systems

S Sharma, TKS Mukkur, HAE Benson… - Journal of pharmaceutical …, 2009 - Elsevier
The nasal route offers a promising opportunity for the delivery of vaccines. This review
analyses the opportunities and novel delivery strategies based on particulate systems for the …

Adjuvants are key factors for the development of future vaccines: lessons from the Finlay adjuvant platform

O Pérez, B Romeu, O Cabrera, E González… - Frontiers in …, 2013 - frontiersin.org
The development of effective vaccines against neglected diseases, especially those
associated with poverty and social deprivation, is urgently needed. Modern vaccine …

Delivery systems: a vaccine strategy for overcoming mucosal tolerance?

JFS Mann, R Acevedo, J Campo, O Pérez… - Expert review of …, 2009 - Taylor & Francis
Antigens administered via the oral and, to a lesser extent, the nasal route are potentially
able to invoke tolerance, resulting in a nonreactive immune response. This has been a …

[HTML][HTML] Human prophylactic vaccine adjuvants and their determinant role in new vaccine formulations

O Pérez, A Batista-Duharte, E González… - Brazilian Journal of …, 2012 - SciELO Brasil
Adjuvants have been considered for a long time to be an accessory and empirical
component of vaccine formulations. However, accumulating evidence of their crucial role in …

Intranasal immunization with a proteoliposome-derived cochleate containing recombinant gD protein confers protective immunity against genital herpes in mice

J Del Campo, M Lindqvist, M Cuello, M Bäckström… - Vaccine, 2010 - Elsevier
The purpose of this study was to investigate the potential of intranasal (IN) immunization with
Neisseria meningitides B proteoliposome (AFPL1) and AFPL1-derived cochleate (AFCo1) …

Effectiveness of a proteoliposome-based vaccine against salmonid rickettsial septicaemia in Oncorhynchus mykiss

M Caruffo, S Vidal, L Santis, D Siel, O Pérez… - Veterinary …, 2021 - Springer
Salmonid rickettsial septicaemia (SRS) is a contagious disease caused by Piscirickettsia
salmonis, an intracellular bacterium. SRS causes an estimated economic loss of $700 …

Intranasal administration of proteoliposome-derived cochleates from Vibrio cholerae O1 induce mucosal and systemic immune responses in mice

R Acevedo, A Callicó, J Del Campo, E González… - Methods, 2009 - Elsevier
Conservative estimates place the death toll from cholera at more than 100,000 persons each
year. A particulate mucosal vaccine strategy combining antigens and immune stimulator …

Adjuvants in vaccines and for immunisation: current trends

P Chiarella, E Massi, M De Robertis… - Expert opinion on …, 2007 - Taylor & Francis
Vaccines represent one of the most successful strategies in medical science. From the
mechanistic perspective, vaccination works by manipulating the immune response through …

OAK‐based cochleates as a novel approach to overcome multidrug resistance in bacteria

L Livne, RF Epand… - The FASEB …, 2010 - Wiley Online Library
Antibiotic resistance has become a worldwide medical problem. To find new ways of
overcoming this phenomenon, we investigated the role of the membrane‐active oligo‐acyl …

Lipid-based cochleates: a promising formulation platform for oral and parenteral delivery of therapeutic agents

R Rao, E Squillante III, KH Kim - Critical Reviews™ in …, 2007 - dl.begellhouse.com
Cochleates are lipid-based supramolecular assemblies that display great potential as
delivery systems for systemic delivery of drugs, including peptides, proteins, vaccines …