GLP-1 receptor agonists: a new treatment in Parkinson's disease

K Kalinderi, V Papaliagkas, L Fidani - International journal of molecular …, 2024 - mdpi.com
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Recent
data highlight similarities between neurodegenerative diseases, including PD and type 2 …

Crosstalk between oxidative stress and inflammation caused by noise and air pollution—implications for neurodegenerative diseases

M Kuntić, O Hahad, T Münzel, A Daiber - Antioxidants, 2024 - mdpi.com
Neurodegenerative diseases are often referred to as diseases of old age, and with the aging
population, they are gaining scientific and medical interest. Environmental stressors, most …

Macroscale connectome topographical structure reveals the biomechanisms of brain dysfunction in Alzheimer's disease

K Zhao, D Wang, D Wang, P Chen, Y Wei, L Tu… - Science …, 2024 - science.org
The intricate spatial configurations of brain networks offer essential insights into
understanding the specific patterns of brain abnormalities and the underlying biological …

Engineered extracellular vesicle-based nanoformulations that coordinate neuroinflammation and immune homeostasis, enhancing parkinson's disease therapy

C Zhang, W Shao, H Yuan, R **ao, Y Zhang, C Wei… - ACS …, 2024 - ACS Publications
Although conventional intervention to microglia can mitigate neuroinflammation in the short
term, immune disorders by peripheral inflammatory cells can infiltrate continuously, resulting …

Dysbiosis of the gut microbiota and its effect on α-synuclein and prion protein misfolding: consequences for neurodegeneration

NU Mahbub, MM Islam, ST Hong… - Frontiers in Cellular and …, 2024 - frontiersin.org
Abnormal behavior of α-synuclein and prion proteins is the hallmark of Parkinson's disease
(PD) and prion illnesses, respectively, being complex neurological disorders. A primary …

Tyrosine hydroxylase inhibitors and dopamine receptor agonists combination therapy for Parkinson's disease

LX Yi, EK Tan, ZD Zhou - International journal of molecular sciences, 2024 - mdpi.com
There are currently no disease-modifying therapies for Parkinson's disease (PD), a
progressive neurodegenerative disorder associated with dopaminergic neuronal loss. There …

Unlocking the potential: semaglutide's impact on Alzheimer's and Parkinson's disease in animal models

AD Meca, IKS Boboc, L Mititelu-Tartau… - Current Issues in …, 2024 - mdpi.com
Semaglutide (SEM), a glucagon-like peptide-1 receptor agonist, has garnered increasing
interest for its potential therapeutic effects in neurodegenerative disorders such as …

Exploring faradaic and non-faradaic electrochemical impedance spectroscopy approaches in Parkinson's disease diagnosis

H Adam, SCB Gopinath, T Adam, MA Fakhri, ET Salim… - Heliyon, 2024 - cell.com
Parkinson's disease is a neurodegenerative condition defined by the progressive death of
dopaminergic neurons in the brain. The diagnosis of Parkinson's disease often uses time …

A novel “off–on” ratiometric aptasensor based on dual-emissive persistent luminescent nanoparticles for the detection of dopamine

R Zhu, L Yu, L Guo, X Ma, Z Meng - Microchemical Journal, 2024 - Elsevier
Dopamine, a neurotransmitter with multiple functions in the brain. The abnormal of
dopamine levels are generally considered to be associated with various nervous system …

Autophagy and neuroprotection in astrocytes exposed to 6-hydroxydopamine is negatively regulated by NQO2: Relevance to Parkinson's disease

E Janda, M Parafati, C Martino, F Crupi… - Scientific Reports, 2023 - nature.com
Dopaminergic degeneration is a central feature of Parkinson's disease (PD), but glial
dysfunction may accelerate or trigger neuronal death. In fact, astrocytes play a key role in the …