Melatonin is a ubiquitous molecule present in almost every live being from bacteria to
humans. In vertebrates, besides being produced in peripheral tissues and acting as an …

Melatonin, more commonly known as the sleep hormone, is mainly secreted by the pineal
gland in dark conditions and regulates the circadian rhythm of the organism. Its intrinsic …

The dual effects of reactive oxygen species (ROS) on living organisms have become a hot
research topic in the biomedical field. Excessive ROS triggers oxidative imbalances in the …

Melatonin, N‐acetyl‐5‐methoxytryptamine, an evolutionally old molecule, is produced by the
pineal gland in vertebrates, and it binds with high affinity to melatonin receptors, which are …

Stroke occurs when a cerebral blood vessel is blocked or ruptured, and it is the major cause
of death and adult disability worldwide. Various pharmacological agents have been …

Oxidative stress plays a critical role in cerebral ischemia/reperfusion (I/R)-induced blood-
brain barrier (BBB) disruption. Panax notoginseng saponins (PNS) possess efficient …

Ischemia/reperfusion (IR) injury occurs in many organs and tissues, and contributes to
morbidity and mortality worldwide. Melatonin, an endogenously produced indolamine …

Postmenopausal osteoporosis (OP) is one of the most common bone diseases that affects
millions of aging women. Reduced osteogenesis and increased oxidative stress have been …

Background Our aims were to evaluate critically the evidence from systematic reviews as
well as narrative reviews of the effects of melatonin (MLT) on health and to identify the …

This analytical review summarizes literature data and our own research on HSP70-
dependent mechanisms of neuroprotection and discusses potential pharmacological agents …