Risk determination and prevention of breast cancer

A Howell, AS Anderson, RB Clarke, SW Duffy… - Breast Cancer …, 2014 - Springer
Breast cancer is an increasing public health problem. Substantial advances have been
made in the treatment of breast cancer, but the introduction of methods to predict women at …

Physical activity in the prevention of human diseases: role of epigenetic modifications

E Grazioli, I Dimauro, N Mercatelli, G Wang, Y Pitsiladis… - BMC genomics, 2017 - Springer
Epigenetic modification refers to heritable changes in gene function that cannot be
explained by alterations in the DNA sequence. The current literature clearly demonstrates …

PAX3 and PAX7 as upstream regulators of myogenesis

M Buckingham, F Relaix - Seminars in cell & developmental biology, 2015 - Elsevier
Like other subclasses within the PAX transcription factor family, PAX3 and PAX7 play
important roles in the emergence of a number of different tissues during development. PAX3 …

Annual Research Review: DNA methylation as a mediator in the association between risk exposure and child and adolescent psychopathology

ED Barker, E Walton, CAM Cecil - Journal of Child Psychology …, 2018 - Wiley Online Library
Background DNA methylation (DNAm) is a potential mechanism for propagating the effects
of environmental exposures on child and adolescent mental health. In recent years, this field …

Are allergic multimorbidities and IgE polysensitization associated with the persistence or re‐occurrence of foetal type 2 signalling? The M e DALL hypothesis

J Bousquet, JM Anto, M Wickman, T Keil, R Valenta… - Allergy, 2015 - Wiley Online Library
Allergic diseases [asthma, rhinitis and atopic dermatitis (AD)] are complex. They are
associated with allergen‐specific IgE and nonallergic mechanisms that may coexist in the …

Multi-omics in HIV: searching insights to understand immunological non-response in PLHIV

S Espineira, M Flores-Piñas, S Chafino… - Frontiers in …, 2023 - frontiersin.org
Antiretroviral therapy (ART) induces persistent suppression of HIV-1 replication and gradual
recovery of T-cell counts, and consequently, morbidity and mortality from HIV-related …

From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?

KS vel Szic, K Declerck, M Vidaković… - Clinical …, 2015 - Springer
The progressively older population in developed countries is reflected in an increase in the
number of people suffering from age-related chronic inflammatory diseases such as …

[HTML][HTML] From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?

K Declerck, M Vidaković… - Clinical …, 2015 - clinicalepigeneticsjournal …
The progressively older population in developed countries is reflected in an increase in the
number of people suffering from age-related chronic inflammatory diseases such as …

Population DNA methylation studies in the Developmental Origins of Health and Disease (DOHaD) framework

JF Felix, CAM Cecil - Journal of developmental origins of health and …, 2019 - cambridge.org
Epigenetic changes represent a potential mechanism underlying associations of early-life
exposures and later life health outcomes. Population-based cohort studies starting in early …

Epigenetics: from the past to the present

NA Villota-Salazar, A Mendoza-Mendoza… - Frontiers in Life …, 2016 - Taylor & Francis
The definition of epigenetics is still under intense debate; however, its concept has evolved
since it was originally introduced in 1939 by Conrad Hal Waddington as a way to reconcile …