Dysfunction of the TP53 (p53) gene occurs in most if not all human malignancies. Two
principal mechanisms are responsible for this dysfunction; mutation and downregulation of …

Lung cancer is the leading cause of cancer-related death across the world. Unlike lung
adenocarcinoma, patients with lung squamous cell carcinoma (LSCC) have not benefitted …

Recent efforts have succeeded in surveying open chromatin at the single-cell level, but high-
throughput, single-cell assessment of heterochromatin and its underlying genomic …

The aberrant expression of squamous lineage markers in pancreatic ductal
adenocarcinoma (PDA) has been correlated with poor clinical outcomes. However, the …

The transcription factor ΔNp63 regulates epithelial stem cell function and maintains the
integrity of stratified epithelial tissues by acting as transcriptional repressor or activator …

The epigenetic regulator, MLL4 (KMT2D), has been described as an essential gene in both
humans and mice. In addition, it is one of the most commonly mutated genes in all of cancer …

Background Cervical cancer (CC) remains a leading cause of gynaecological cancer-
related mortality with infection by human papilloma virus (HPV) being the most important risk …

The p53 protein family is the most studied protein family of all. Sequence analysis and
structure determination have revealed a high similarity of crucial domains between p53, p63 …

Sarcomatoid urothelial bladder cancer (SARC) displays a high propensity for distant
metastasis and is associated with short survival. We report a comprehensive genomic …

ABSTRACT p63 (also known as TP63) is a transcription factor of the p53 family, along with
p73. Multiple isoforms of p63 have been discovered and these have diverse functions …