Conspectus Cellular senescence can be defined as an irreversible stop** of cell
proliferation that arises in response to various stress signals. Cellular senescence is …

Aging exhibits several hallmarks in common with cancer, such as cellular senescence,
dysbiosis, inflammation, genomic instability, and epigenetic changes. In recent decades …

Cellular senescence is a permanent state of cell cycle arrest characterized by increased
activity of senescence associated β-galactosidase (SA-β-gal). Notably, cancer cells have …

Senescence is an important biological process, which leads to the gradual degradation of its
physiological function and increases morbidity and mortality. Herein, a novel ratiometric …

Abstract Beta-galactosidase (β-gal), a typical glycosidase catalyzing the hydrolysis of
glycosidic bonds, is regarded as a vital biomarker for cell senescence and cancer …

Though palbociclib, a cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor has been
approved for treating breast cancer, two major clinical challenges remain:(i) Triple-negative …

Specific identification and monitoring of senescent cells are essential for the in-depth
understanding and regulation of senescence-related life processes and diseases …

Senescence is a crucial hallmark of ageing and a significant contributor to the pathology of
age-related disorders. As committee members of the young International Cell Senescence …

Cellular senescence is not only a key component of the natural aging process driven by
multiple factors but is also closely linked to the development of age-related diseases such as …

Введение. Накопление сенесцентных клеток с возрастом принято считать одной из
причин дисфункции различных органов и тканей при старении организма. Иммунная …