Neuromuscular disorders comprise a diverse group of human inborn diseases that arise
from defects in the structure and/or function of the muscle tissue—encompassing the muscle …

Sarcopenia is a systemic disease with progressive and generalized skeletal muscle
dysfunction defined by age-related low muscle mass, high content of muscle slow fibers, and …

Glucocorticoid steroids are commonly prescribed for many inflammatory conditions, but
chronic daily use produces adverse effects, including muscle wasting and weakness. In …

Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disease caused by
mutations to the dystrophin gene, resulting in deficiency of dystrophin protein, loss of …

Exogenous glucocorticoids interact with the circadian clock, but little attention is paid to the
timing of intake. We recently found that intermittent once-weekly prednisone improved …

Duchenne muscular dystrophy (DMD) is a devastating disease affecting approximately 1 in
every 3,500 male births worldwide. Multiple mutations in the dystrophin gene have been …

Duchenne muscular dystrophy (DMD) is a devastating genetic disease leading to
degeneration of skeletal muscles and premature death. How dystrophin absence leads to …

Inhibiting glycogen synthase kinase 3 (GSK3) improves muscle function, metabolism, and
bone health in many diseases and conditions; however, whether GSK3 should be targeted …

Deflazacort and prednisone/prednisolone are the current standard of care for patients with
Duchenne muscular dystrophy (DMD) based on evidence that they improve muscle strength …

New medicines are urgently required to treat the fatal neuromuscular disease Duchenne
muscular dystrophy (DMD). Dimethyl fumarate (DMF) is a potent immunomodulatory small …