[HTML][HTML] Exercise-specific adaptations in human skeletal muscle: Molecular mechanisms of making muscles fit and mighty

ACQ Thomas, CA Stead, JG Burniston… - Free Radical Biology and …, 2024 - Elsevier
The mechanisms leading to a predominantly hypertrophied phenotype versus a
predominantly oxidative phenotype, the hallmarks of resistance training (RT) or aerobic …

Maintaining proteostasis under mechanical stress

J Höhfeld, T Benzing, W Bloch, DO Fürst, S Gehlert… - EMBO …, 2021 - embopress.org
Cell survival, tissue integrity and organismal health depend on the ability to maintain
functional protein networks even under conditions that threaten protein integrity. Protection …

Filamin C in cardiomyopathy: from physiological roles to DNA variants

S Song, A Shi, H Lian, S Hu, Y Nie - Heart Failure Reviews, 2022 - Springer
Cardiomyopathy affects approximately 1 in 500 adults and is the leading cause of death.
Familial cases are common, and mutations in many genes are involved in cardiomyopathy …

Mimicking exercise in vitro: effects of myotube contractions and mechanical stretch on omics

JH Lautaoja, DC Turner, AP Sharples… - … of Physiology-Cell …, 2023 - journals.physiology.org
The number of studies using skeletal muscle (SkM) cell culture models to study exercise in
vitro are rapidly expanding. Progressively, more comprehensive analysis methods, such as …

Protein phosphatase-1 regulates the binding of filamin C to FILIP1 in cultured skeletal muscle cells under mechanical stress

T Kokot, JP Zimmermann, AN Schwäble, L Reimann… - Scientific Reports, 2024 - nature.com
The actin-binding protein filamin c (FLNc) is a key mediator in the response of skeletal
muscle cells to mechanical stress. In addition to its function as a structural scaffold, FLNc …

Post-natal muscle growth and protein turnover: a narrative review of current understanding

DJ Millward - Nutrition research reviews, 2023 - cambridge.org
A model explaining the dietary-protein driven post-natal skeletal muscle growth and protein
turnover in the rat is updated, and the mechanisms involved described in this narrative …

GePI: large-scale text mining, customized retrieval and flexible filtering of gene/protein interactions

E Faessler, U Hahn, S Schäuble - Nucleic Acids Research, 2023 - academic.oup.com
We present GePI, a novel Web server for large-scale text mining of molecular interactions
from the scientific biomedical literature. GePI leverages natural language processing …

Phosphoproteomics profiling defines a target landscape of the basophilic protein kinases AKT, S6K, and RSK in skeletal myotubes

AL Fricke, WWD Mühlhäuser… - Journal of Proteome …, 2023 - ACS Publications
Phosphorylation-dependent signal transduction plays an important role in regulating the
functions and fate of skeletal muscle cells. Central players in the phospho-signaling network …

Identification of copy number variations in the genome of Dairy Gir cattle

LG Braga, TCS Chud, RN Watanabe, RP Savegnago… - Plos one, 2023 - journals.plos.org
Studying structural variants that can control complex traits is relevant for dairy cattle
production, especially for animals that are tolerant to breeding conditions in the tropics, such …

Dynamic changes to the skeletal muscle proteome and ubiquitinome induced by the E3 ligase, ASB2β

CA Goodman, JR Davey, A Hagg, BL Parker… - Molecular & Cellular …, 2021 - ASBMB
Ubiquitination is a posttranslational protein modification that has been shown to have a
range of effects, including regulation of protein function, interaction, localization, and …