Both obesity and overweight are increasing worldwide and have detrimental influences on
several human body functions including the reproductive health. In particular, obese women …

The worldwide upward trend in obesity has been dramatic, now affecting more than 20% of
American women of reproductive age. Obesity is associated with many adverse maternal …

An equilibrium needs to be established by the cellular and acellular components of the
ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus …

Contemporary scientists need no “p value” and “relative risk” statistics to be exquisitely
aware of the increasing prevalence of obesity and complications posed by obesity. It is now …

Over-nutrition in females causes altered fetal growth during pregnancy and permanently
programs the metabolism of offspring; however, the temporal and mechanistic origins of …

Female fertility is inversely correlated with maternal age due to a depletion of the oocyte
pool and a reduction in oocyte developmental competence. Few studies have addressed the …

STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in
embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight …

Obesity is associated with infertility in women through multiple and complex mechanisms.
Briefly, the adipose tissue through the production of many factors, such as leptin, free fatty …

Maternal obesity in humans is associated with poor outcomes across the reproductive
spectrum. Emerging evidence indicates that these defects are likely attributed to factors …

Obesity, diabetes, and related metabolic disorders are major health issues worldwide. As
the epidemic of metabolic disorders continues, the associated medical co-morbidities …