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Mitochondrial dynamics and its involvement in disease
DC Chan - Annual review of pathology: mechanisms of disease, 2020 - annualreviews.org
The dynamic properties of mitochondria—including their fusion, fission, and degradation—
are critical for their optimal function in energy generation. The interplay of fusion and fission …
are critical for their optimal function in energy generation. The interplay of fusion and fission …
Mitochondrial DNA copy number in human disease: the more the better?
Most of the genetic information has been lost or transferred to the nucleus during the
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …
POLG-related disorders and their neurological manifestations
The POLG gene encodes the mitochondrial DNA polymerase that is responsible for
replication of the mitochondrial genome. Mutations in POLG can cause early childhood …
replication of the mitochondrial genome. Mutations in POLG can cause early childhood …
Mitochondrial fusion, fission, and mitochondrial toxicity
Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial
fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as …
fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as …
Disturbed mitochondrial dynamics and neurodegenerative disorders
Mitochondria form a highly interconnected tubular network throughout the cell via a dynamic
process, with mitochondrial segments fusing and breaking apart continuously. Strong …
process, with mitochondrial segments fusing and breaking apart continuously. Strong …
[HTML][HTML] Mitochondrial DNA maintenance defects
The maintenance of mitochondrial DNA (mtDNA) depends on a number of nuclear gene-
encoded proteins including a battery of enzymes forming the replisome needed to …
encoded proteins including a battery of enzymes forming the replisome needed to …
A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement
S Bannwarth, S Ait-El-Mkadem, A Chaussenot… - Brain, 2014 - academic.oup.com
Mitochondrial DNA instability disorders are responsible for a large clinical spectrum, among
which amyotrophic lateral sclerosis-like symptoms and frontotemporal dementia are …
which amyotrophic lateral sclerosis-like symptoms and frontotemporal dementia are …
Mitochondria, oxidative stress and neurodegeneration
Mitochondria are involved in ATP supply to cells through oxidative phosphorylation
(OXPHOS), synthesis of key molecules and response to oxidative stress, as well as in …
(OXPHOS), synthesis of key molecules and response to oxidative stress, as well as in …
Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity
Mitochondria are dynamic organelles that continually move, fuse and divide. The dynamic
balance of fusion and fission of mitochondria determines their morphology and allows their …
balance of fusion and fission of mitochondria determines their morphology and allows their …
Mitochondria as a target of environmental toxicants
Enormous strides have recently been made in our understanding of the biology and
pathobiology of mitochondria. Many diseases have been identified as caused by …
pathobiology of mitochondria. Many diseases have been identified as caused by …