Gene expression involves transcription, translation and the turnover of mRNAs and proteins.
The degree to which protein abundances scale with mRNA levels and the implications in …

Many research questions in fields such as personalized medicine, drug screens or systems
biology depend on obtaining consistent and quantitatively accurate proteomics data from …

The proteome provides unique insights into disease biology beyond the genome and
transcriptome. A lack of large proteomic datasets has restricted the identification of new …

Proteins are essential agents of biological processes. To date, large-scale profiling of cell
line collections including the Cancer Cell Line Encyclopedia (CCLE) has focused primarily …

Summary Lung cancer in East Asia is characterized by a high percentage of never-smokers,
early onset and predominant EGFR mutations. To illuminate the molecular phenotype of this …

Artificial intelligence and machine learning (ML) promise to transform cancer therapies by
accurately predicting the most appropriate therapies to treat individual patients. Here, we …

Abstract Inactivation of Polybromo 1 (PBRM1), a specific subunit of the PBAF chromatin
remodeling complex, occurs frequently in cancer, including 40% of clear cell renal cell …

Targeted therapies, chemotherapy, and immunotherapy are used to treat patients with
mismatch repair–deficient (dMMR)/microsatellite instability-high (MSI-H) colorectal cancer …

Abstract Background The National Cancer Institute drug pair screening effort against 60 well-
characterized human tumor cell lines (NCI-60) presents an unprecedented resource for …

Understanding the dynamics of endogenous protein–protein interactions in complex
networks is pivotal in deciphering disease mechanisms. To enable the in-depth analysis of …