[HTML][HTML] Proteogenomics-guided functional venomics resolves the toxin arsenal and activity of Deinagkistrodon acutus venom

I Avella, L Schulte, S Hurka, M Damm… - International Journal of …, 2024 - Elsevier
Snakebite primarily impacts rural communities of Africa, Asia, and Latin America. The sharp-
nosed viper (Deinagkistrodon acutus) is among the snakes of highest medical importance in …

Determining the pharmacological potential and biological role of linear pseudoscorpion toxins via functional profiling

P Erkoc, S Schiffmann, T Ulshöfer, M Henke, M Marner… - Iscience, 2024 - cell.com
Arthropod venoms contain bioactive molecules attractive for biomedical applications.
However, few of these have been isolated, and only a tiny number has been characterized …

Functional Profiling of the A-Family of Venom Peptides from the Wolf Spider Lycosa shansia

T Lüddecke, L Dersch, L Schulte, S Hurka, A Paas… - Toxins, 2023 - mdpi.com
The venoms of spiders from the RTA (retro-lateral tibia apophysis) clade contain diverse
short linear peptides (SLPs) that offer a rich source of therapeutic candidates. Many of these …

Comparative venom analysis between melanistic and normally coloured phenotypes of the common adder (Vipera berus)

L Schulte, L Uhrig, J Eichberg… - Royal Society …, 2024 - royalsocietypublishing.org
Snake venom is an ecologically relevant functional trait directly linked with a snake's fitness
and survival, facilitating predation and defence. Snake venom variation occurs at all …

[HTML][HTML] Discovery of an insect neuroactive helix ring peptide from ant venom

V Barassé, L Jouvensal, G Boy, A Billet, S Ascoët… - Toxins, 2023 - mdpi.com
Ants are among the most abundant terrestrial invertebrate predators on Earth. To overwhelm
their prey, they employ several remarkable behavioral, physiological, and biochemical …

[HTML][HTML] The Toxin Diversity, Cytotoxicity, and Enzymatic Activity of Cape Cobra (Naja nivea) Venom

T Lüddecke, I Avella, M Damm, L Schulte, J Eichberg… - Toxins, 2024 - mdpi.com
“True” cobras (genus Naja) are among the venomous snakes most frequently involved in
snakebite accidents in Africa and Asia. The Cape cobra (Naja nivea) is one of the African …

[HTML][HTML] Screening of antimicrobial activity in venom: Exploring key parameters

A Ouertani, C Mollet, Y Boughanmi, H de Pomyers… - Toxicon, 2024 - Elsevier
The escalating challenge of antibiotic resistance significantly threatens global health,
underscoring the critical need for new antimicrobial agents. Venoms, increasingly …

[HTML][HTML] Engineering a wolf spider A-family toxin towards increased antimicrobial activity but low toxicity

L Dersch, A Stahlhut, J Eichberg, A Paas, K Hardes… - Toxicon, 2024 - Elsevier
Spider-derived peptides with insecticidal, antimicrobial and/or cytolytic activities, also known
as spider venom antimicrobial peptides (AMPs), can be found in the venoms of RTA-clade …

Effect from dinoponeratoxin M-PONTXDq3a arginine and lysine substituted analogues against Staphylococcus aureus strains

PN da Silva Júnior, JVS Nunes, BR Duque… - Toxicon, 2023 - Elsevier
The growing incidence of methicillin-resistant Staphylococcus aureus (MRSA) infections is
associated with increased mortality rates, which has generated interest in the development …

Heilende Gifte: Vergangenheit, Gegenwart und Zukunft von Tiergiften in der biomedizinischen Wirkstoffforschung

T Lüddecke - Tiere in der Medizin, 2024 - brill.com
Seit Jahrtausenden sind Menschen von giftigen Tieren fasziniert. Sie erscheinen, oftmals als
bösartige Monstrositäten, in Sagen und Mythen aller Völker rund um den Erdball. Diese …