The voltage-gated sodium channel NaV1. 7 is preferentially expressed in peripheral somatic
and visceral sensory neurons, olfactory sensory neurons and sympathetic ganglion neurons …

While considerable effort has been made to investigate the neural mechanisms of pain,
much less effort has been devoted to itch, at least until recently. However, itch is now gaining …

Pathogenic variants in the voltage-gated sodium channel gene family lead to early onset
epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral …

Sodium channel Nav1. 9 is expressed in peripheral nociceptive neurons, as well as visceral
afferents, and has been shown to act as a threshold channel. Painful peripheral neuropathy …

The discovery of genetic variants that substantially alter an individual's perception of pain
has led to a step-change in our understanding of molecular events underlying the detection …

Objective To test the hypothesis that peripheral C nociceptor function may be abnormal in
fibromyalgia and that C nociceptor dysfunction may contribute to the symptoms reported by …

Background Current standard of care for trigeminal neuralgia is treatment with the sodium
channel blockers carbamazepine and oxcarbazepine, which although effective are …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Abstract Small-fibre neuropathy (SFN), a disorder of thinly myelinated Aδ-fibres and
unmyelinated C-fibres, is clinically characterized by neuropathic pain symptoms and …

Background and purpose Small fiber neuropathy (SFN) is a common disorder leading to
neuropathic pain and autonomic symptoms. The objective of this study was to investigate …