Glutamate's role as a neurotransmitter at synapses has been known for 40 years, but
glutamate has since been shown to regulate neurogenesis, neurite outgrowth …

Since 1975, Robert Julien's A Primer of Drug Action has been the definitive guide to the
effects of psychoactive drugs on the brain and on behavior. Now fully updated, this popular …

Background: Hypofunction of N-methyl-D-aspartate (NMDA) subtype glutamate receptor has
been implicated in the pathophysiology of schizophrenia. D-serine is a full agonist of the …

The discovery of allosteric modulators of G protein-coupled receptors (GPCRs) provides a
promising new strategy with potential for develo** novel treatments for a variety of central …

Schizophrenia is a common and debilitating illness, characterized by chronic psychotic
symptoms and psychosocial impairment that exact considerable human and economic …

Despite great advances in basic neuroscience knowledge, the improved understanding of
brain functioning has not yet led to the introduction of truly novel pharmacological …

It was investigated whether subchronic application of 30 mg/kg ketamine (Ket) induces
reliable changes in behaviour and parameters of dopaminergic, glutamatergic, and …

BACKGROUND: Hypofunction of N-methyl-D-aspartate glutamate receptor had been
implicated in the pathophysiology of schizophrenia. Treatment with D-serine or glycine …

Rationale Latent inhibition (LI), namely, poorer performance on a learning task involving a
previously pre-exposed non-reinforced stimulus, is disrupted in the rat by the dopamine (DA) …

This article considers the possibility that defective interactions among distributed brain areas
may underlie certain dysfunctions of conscious integration such as those seen in …