Isobaric labeling-based relative quantification in shotgun proteomics
Mass spectrometry plays a key role in relative quantitative comparisons of proteins in order
to understand their functional role in biological systems upon perturbation. In this review, we …
to understand their functional role in biological systems upon perturbation. In this review, we …
Analysis of the plasma proteome using iTRAQ and TMT‐based Isobaric labeling
R Moulder, SD Bhosale, DR Goodlett… - Mass spectrometry …, 2018 - Wiley Online Library
Over the past decade, chemical labeling with isobaric tandem mass tags, such as isobaric
tags for relative and absolute quantification reagents (iTRAQ) and tandem mass tag (TMT) …
tags for relative and absolute quantification reagents (iTRAQ) and tandem mass tag (TMT) …
TMTpro: design, synthesis, and initial evaluation of a proline-based isobaric 16-plex tandem mass tag reagent set
A Thompson, N Wölmer, S Koncarevic… - Analytical …, 2019 - ACS Publications
The design and synthesis of a proline-based reporter isobaric Tandem Mass Tag structure
(TMTpro) is presented. An analysis is made of the performance of the new TMTpro tags in …
(TMTpro) is presented. An analysis is made of the performance of the new TMTpro tags in …
Plasma biomarkers for mild cognitive impairment and Alzheimer's disease
Purpose of review: With the move toward development of disease modifying treatments,
there is a need for more specific diagnosis of early Alzheimer's disease (AD) and mild …
there is a need for more specific diagnosis of early Alzheimer's disease (AD) and mild …
An integrated quantitative proteomics workflow for cancer biomarker discovery and validation in plasma
Blood plasma is one of the most widely used samples for cancer biomarker discovery
research as well as clinical investigations for diagnostic and therapeutic purposes. However …
research as well as clinical investigations for diagnostic and therapeutic purposes. However …
Identification of a panel of novel serum osteoarthritis biomarkers
P Fernández-Puente, J Mateos… - Journal of proteome …, 2011 - ACS Publications
Osteoarthritis (OA) is the most common rheumatic pathology. Because currently available
diagnostic methods are limited and lack sensitivity, the identification of new specific …
diagnostic methods are limited and lack sensitivity, the identification of new specific …
Proteomic analyses reveal high expression of decorin and endoplasmin (HSP90B1) are associated with breast cancer metastasis and decreased survival
Background Breast cancer is the most common malignancy among women worldwide in
terms of incidence and mortality. About 10% of North American women will be diagnosed …
terms of incidence and mortality. About 10% of North American women will be diagnosed …
Plasma-derived exosomal ALIX as a novel biomarker for diagnosis and classification of pancreatic cancer
J Yang, Y Zhang, X Gao, Y Yuan, J Zhao, S Zhou… - Frontiers in …, 2021 - frontiersin.org
Background Pancreatic cancer (PC) has a dismal prognosis due to its insidious early
symptoms and poor early detection rate. Exosomes can be released by various cell types …
symptoms and poor early detection rate. Exosomes can be released by various cell types …
Glycoproteomics in neurodegenerative diseases
H Hwang, J Zhang, KA Chung… - Mass spectrometry …, 2010 - Wiley Online Library
Protein glycosylation regulates protein function and cellular distribution. Additionally,
aberrant protein glycosylations have been recognized to play major roles in human …
aberrant protein glycosylations have been recognized to play major roles in human …
Identification of candidate biomarkers of therapeutic response to docetaxel by proteomic profiling
Docetaxel chemotherapy improves symptoms and survival in men with metastatic hormone-
refractory prostate cancer (HRPC). However,∼ 50% of patients do not respond to Docetaxel …
refractory prostate cancer (HRPC). However,∼ 50% of patients do not respond to Docetaxel …