Continuous manufacturing has been applied in many different industries but has been
pursued reluctantly in biotechnology where the batchwise process is still the standard. A …

Due to the lack of development in the area of sample preparation, few complete lab-on-a-
chip systems have appeared in recent years that can deal with raw samples. Cell lysis and …

Objective: To evaluate the efficacy of two simple methods involving use of heat for extraction
of bacterial deoxyribonucleic acid (DNA) be used in molecular techniques like polymerase …

The merits of continuous processing over batch processing are well known in the
manufacturing industry. Continuous operation results in shorter process times due to …

Intracellular components containing information about genetic and disease characteristics
are key substances to clinical diagnostics. Cell lysis is therefore a crucial step for efficient …

This review covers three aspects of PCR-based microfluidic chip assays: sample
preparation, target amplification, and product detection. We also discuss the challenges …

We present a unique bubble generation technique in microfluidic chips using continuous-
wave laser-induced heat and demonstrate its application by creating micro-valves and micro …

The outbreak of COVID-19 makes epidemic prevention and control become a growing
global concern. Nucleic acid amplification testing (NAAT) can realize early and rapid …

The ability to isolate sc (supercoiled) pDNA (plasmid DNA) isoform should be one of the
features of a pDNA purification process, eliminating sample contaminants such as RNA …

Process Validation in Manufacturing of Biopharmaceuticals, Third Edition delves into the key
aspects and current practices of process validation. It includes discussion on the final …