Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
G protein–coupled receptor oligomerization revisited: functional and pharmacological perspectives
Most evidence indicates that, as for family CG protein–coupled receptors (GPCRs), family A
GPCRs form homo-and heteromers. Homodimers seem to be a predominant species, with …
GPCRs form homo-and heteromers. Homodimers seem to be a predominant species, with …
Action of molecular switches in GPCRs-theoretical and experimental studies
G protein coupled receptors (GPCRs), also called 7TM receptors, form a huge superfamily of
membrane proteins that, upon activation by extracellular agonists, pass the signal to the cell …
membrane proteins that, upon activation by extracellular agonists, pass the signal to the cell …
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
Opium is one of the world's oldest drugs, and its derivatives morphine and codeine are
among the most used clinical drugs to relieve severe pain. These prototypical opioids …
among the most used clinical drugs to relieve severe pain. These prototypical opioids …
Single-molecule analysis of fluorescently labeled G-protein–coupled receptors reveals complexes with distinct dynamics and organization
G-protein–coupled receptors (GPCRs) constitute the largest family of receptors and major
pharmacological targets. Whereas many GPCRs have been shown to form di-/oligomers, the …
pharmacological targets. Whereas many GPCRs have been shown to form di-/oligomers, the …
Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling
MJ Lohse, S Nuber, C Hoffmann - Pharmacological reviews, 2012 - Elsevier
Fluorescence and bioluminescence resonance energy transfer (FRET and BRET)
techniques allow the sensitive monitoring of distances between two labels at the nanometer …
techniques allow the sensitive monitoring of distances between two labels at the nanometer …
A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors
G‐protein‐coupled receptors (GPCRs) can form heteromeric complexes. Herein'we describe
a new approach to test the heteromerization of 2 receptors' or 2 receptor subunits' and to …
a new approach to test the heteromerization of 2 receptors' or 2 receptor subunits' and to …
Conformational selection or induced fit? 50 years of debate resolved
Exactly 50 years ago, biochemists raised the question of the mechanism of the
conformational change that mediates “allosteric” interactions between regulatory sites and …
conformational change that mediates “allosteric” interactions between regulatory sites and …
Crystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal state
J Huang, S Chen, JJ Zhang, XY Huang - Nature structural & molecular …, 2013 - nature.com
G protein–coupled receptors (GPCRs) mediate transmembrane signaling. Before ligand
binding, GPCRs exist in a basal state. Crystal structures of several GPCRs bound with …
binding, GPCRs exist in a basal state. Crystal structures of several GPCRs bound with …
Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism
A Kern, R Albarran-Zeckler, HE Walsh, RG Smith - Neuron, 2012 - cell.com
We identified subsets of neurons in the brain that coexpress the dopamine receptor subtype-
2 (DRD2) and the ghrelin receptor (GHSR1a). Combination of FRET confocal microscopy …
2 (DRD2) and the ghrelin receptor (GHSR1a). Combination of FRET confocal microscopy …
[HTML][HTML] The endocannabinoid system as a target in cancer diseases: are we there yet?
The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …
decade. The immense data load published on its dual role in both tumorigenesis and …