Reagents that bind tightly and specifically to biomolecules of interest remain essential in the
exploration of biology and in their ultimate application to medicine. Besides ligands for …

Nanobodies are antibody fragments derived from camelids, naturally endowed with
properties like low molecular weight, high affinity and low immunogenicity, which contribute …

A growing number of optogenetic tools have been developed to reversibly control binding
between two engineered protein domains. In contrast, relatively few tools confer light …

A standard procedure to study cellular elements is via immunostaining followed by optical
imaging. This methodology typically requires target-specific primary antibodies (1. Abs) …

Tripartite ATP-independent periplasmic (TRAP) transporters are found widely in bacteria
and archaea and consist of three structural domains, a soluble substrate-binding protein (P …

Lipopolysaccharides are major constituents of the extracellular leaflet in the bacterial outer
membrane and form an effective physical barrier for environmental threats and for antibiotics …

In biomedical research, there is an ongoing demand for new technologies to elucidate
disease mechanisms and develop novel therapeutics. This requires comprehensive …

ABC exporters harness the energy of ATP to pump substrates across membranes.
Extracellular gate opening and closure are key steps of the transport cycle, but the …

Nanobodies (nAbs) are small, minimal antibodies that have distinct attributes that make
them uniquely suited for certain biomedical research, diagnostic and therapeutic …

Binding protein generation typically relies on laborious screening cascades that process
candidate molecules individually. We have developed NestLink, a binder selection and …