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Transmitted drug resistance to integrase-based first-line human immunodeficiency virus antiretroviral regimens in Mediterranean Europe
A de Salazar, L Viñuela, A Fuentes… - Clinical Infectious …, 2023 - academic.oup.com
Background We evaluated the prevalence of transmitted drug resistance (TDR) to integrase
strand-transfer inhibitors (INSTIs) and nucleoside/nucleotide reverse transcriptase inhibitors …
strand-transfer inhibitors (INSTIs) and nucleoside/nucleotide reverse transcriptase inhibitors …
[PDF][PDF] Antiviral properties of chalcones and their synthetic derivatives: a mini review
Chalcones (natural or synthetic derivatives) are aromatic ketones possessing a central
backbone that form a core for variety important compounds with different substitutions …
backbone that form a core for variety important compounds with different substitutions …
Safety, tolerability, and pharmacokinetics of single‐and multiple‐dose administration of islatravir (MK‐8591) in adults without HIV
RP Matthews, W Ankrom, E Friedman… - Clinical and …, 2021 - Wiley Online Library
Abstract Islatravir (MK‐8591) is a nucleoside analogue in development for the treatment and
prevention of HIV‐1. Two phase 1 trials were conducted during initial evaluation of islatravir …
prevention of HIV‐1. Two phase 1 trials were conducted during initial evaluation of islatravir …
HAMLET, a protein complex from human milk, has bactericidal activity and enhances the activity of antibiotics against pathogenic Streptococci
F Alamiri, K Riesbeck… - Antimicrobial Agents and …, 2019 - journals.asm.org
ABSTRACT HAMLET (h uman a lpha-lactalbumin m ade le thal to t umor cells) is a protein-
lipid complex derived from human milk that was first described for its tumoricidal activity …
lipid complex derived from human milk that was first described for its tumoricidal activity …
Resistance-informed versus empirical management of viraemia in children and adolescents with HIV in Lesotho and Tanzania (GIVE MOVE trial): a multisite, open …
JA Brown, IK Ringera, E Luoga, M Bresser… - The Lancet Global …, 2024 - thelancet.com
Background Children and adolescents with HIV taking antiretroviral therapy (ART) have high
rates of viraemia. We assessed if genotypic resistance testing (GRT) to inform onward …
rates of viraemia. We assessed if genotypic resistance testing (GRT) to inform onward …
Clinical impact and cost-effectiveness of genotype testing at human immunodeficiency virus diagnosis in the United States
Background US guidelines recommend genotype testing at human immunodeficiency virus
(HIV) diagnosis (“baseline genotype”) to detect transmitted drug resistance (TDR) to …
(HIV) diagnosis (“baseline genotype”) to detect transmitted drug resistance (TDR) to …
Lack of a clinically meaningful drug interaction between the HIV‐1 antiretroviral agents islatravir, dolutegravir, and tenofovir disoproxil fumarate
DJ Rudd, S Zhang, KL Fillgrove… - Clinical …, 2021 - Wiley Online Library
Islatravir, an investigational nucleoside reverse transcriptase translocation inhibitor, is in
clinical development for the treatment and prevention of HIV‐1 infection. Because islatravir …
clinical development for the treatment and prevention of HIV‐1 infection. Because islatravir …
Effectiveness of transmitted drug resistance testing before initiation of antiretroviral therapy in HIV-positive individuals
Background: For people living with HIV, major guidelines in high-income countries
recommend testing for transmitted drug resistance (TDR) to guide the choice of first-line …
recommend testing for transmitted drug resistance (TDR) to guide the choice of first-line …
HIV-1 drug resistance genoty** success rates and correlates of Dried-blood spots and plasma specimen genoty** failure in a resource-limited setting
J Omooja, N Bbosa, DB Lule, M Nannyonjo… - BMC Infectious …, 2022 - Springer
Background HIV-1 drug resistance genoty** is critical to the monitoring of antiretroviral
treatment. Data on HIV-1 genoty** success rates of different laboratory specimen types …
treatment. Data on HIV-1 genoty** success rates of different laboratory specimen types …
Genotype-Informed versus empiric management of viremia (give move): study protocol of an open-label randomised clinical trial in children and adolescents living …
JA Brown, I Ringera, E Luoga, M Cheleboi… - BMC infectious …, 2020 - Springer
Background Globally, the majority of people living with HIV have no or only limited access to
HIV drug resistance testing to guide the selection of antiretroviral drugs. This is of particular …
HIV drug resistance testing to guide the selection of antiretroviral drugs. This is of particular …