Policy Points: Currently, there is massive production of unnecessary, misleading, and
conflicted systematic reviews and meta‐analyses. Instead of promoting evidence‐based …

Background The efficacy of antidepressant medication has been shown empirically to be
overestimated due to publication bias, but this has only been inferred statistically with regard …

An examination of the uses of data within a changing knowledge infrastructure, offering
analysis and case studies from the sciences, social sciences, and humanities.“Big Data” is …

High quality protocols facilitate proper conduct, reporting, and external review of clinical
trials. However, the completeness of trial protocols is often inadequate. To help improve the …

Scientific publication is immensely important to the scientific endeavour. There is, however,
concern that rewarding scientists chiefly on publication creates a perverse incentive …

Objective To determine rates of publication and reporting of results within two years for all
completed clinical trials registered in ClinicalTrials. gov across leading academic medical …

Objective To estimate the frequency with which results of large randomized clinical trials
registered with ClinicalTrials. gov are not available to the public. Design Cross sectional …

Objectives To analyse developments (and their causes) in the number and proportion of
clinical trials that were registered in different parts of the world after the International …

Background Information and communication technologies have long become prominent
components of health systems. Rapid advances in digital technologies and data science …

Importance Drugs treating serious or life-threatening conditions can receive US Food and
Drug Administration (FDA) accelerated approval based on showing an effect in surrogate …