PVT1 lncRNA in lung cancer: A key player in tumorigenesis and therapeutic opportunities

MA Hakami, A Hazazi, FR Khan, O Abdulaziz… - … -Research and Practice, 2024 - Elsevier
The lncRNA PVT1 has emerged as a pivotal component in the intricate landscape of cancer
pathogenesis, particularly in lung cancer. PVT1, situated in the 8q24 chromosomal region …

Crosstalk of lncRNA and cellular metabolism and their regulatory mechanism in cancer

YH Lin - International journal of molecular sciences, 2020 - mdpi.com
The imbalanced regulation of metabolic homeostasis and energy production is highly
associated with inflammation, tumor growth, metastasis and cancer progression. Both …

Exosomal lncRNA PVT1/VEGFA axis promotes colon cancer metastasis and stemness by downregulation of tumor suppressor miR‐152‐3p

SW Lai, MY Chen, OA Bamodu… - Oxidative Medicine …, 2021 - Wiley Online Library
Background. Treating advanced colon cancer remains challenging in clinical settings
because of the development of drug resistance and distant metastasis. Mechanisms …

PVT1 inhibition stimulates anti-tumor immunity, prevents metastasis, and depletes cancer stem cells in squamous cell carcinoma

Z Qin, W Zhang, S Liu, Y Wang, X Peng, L Jia - Cell Death & Disease, 2023 - nature.com
Cancer stem cells (CSCs) cause tumor metastasis and immune evasion by as-yet-unknown
molecular mechanisms. In the present study, we identify a long noncoding RNA (lncRNA) …

LncRNAs has been identified as regulators of Myeloid-derived suppressor cells in lung cancer

Y Liu, Y Han, Y Zhang, T Lv, X Peng… - Frontiers in …, 2023 - frontiersin.org
Lung tumours are widespread pathological conditions that attract much attention due to their
high incidence of death. The immune system contributes to the progression of these …

Integrative genomic analyses identify lncRNA regulatory networks across pediatric leukemias and solid tumors

A Modi, G Lopez, KL Conkrite, C Su, TC Leung… - Cancer research, 2023 - AACR
Long noncoding RNAs (lncRNA) play an important role in gene regulation and contribute to
tumorigenesis. While pan-cancer studies of lncRNA expression have been performed for …

LncRNA PVT1: as a therapeutic target for breast cancer

KJ Baljon, P Ramaiah, EAM Saleh, F Al-Dolaimy… - … -Research and Practice, 2023 - Elsevier
A significant number of women are identified with breast cancer (BC) every year, making it
among the most prevalent malignancies and one of the leading causes of mortality globally …

Association of MALAT1 and PVT1 variants, expression profiles and target miRNA-101 and miRNA-186 with colorectal cancer: correlation with epithelial-mesenchymal …

AF Radwan, OG Shaker, NA El-Boghdady… - International journal of …, 2021 - mdpi.com
The influence of PVT1 and MALAT1 variants on colorectal cancer (CRC) susceptibility and
their impact on PVT1/miRNA-186/epithelial-mesenchymal transition (EMT) and …

Diagnostic and therapeutic implications of long non-coding rnas in leukemia

V Gasic, T Karan-Djurasevic, D Pavlovic, B Zukic… - Life, 2022 - mdpi.com
Simple Summary Research on leukemia has often led to novel approaches in clinical
practice. Cytogenetical and molecular markers have been introduced in treatment protocols …

lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer

AA Bhat, M Afzal, E Moglad, R Thapa, H Ali… - Clinical and …, 2024 - Springer
Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular
processes, including cancer progression and stress response. Recent studies have …