Cutaneous leishmaniasis has been endemic since decades. Millions of cases are reported
worldwide specially in develo** and underdeveloped countries. There are 2 major types …

Alkylphospholipids (APLs) represent a new class of drugs which do not interact directly with
DNA but act on the cell membrane where they accumulate and interfere with lipid …

Melanoma is responsible for more than 80% of deaths related to skin diseases. Ibrutinib
(IBR), a Bruton's tyrosine kinase inhibitor, has been proposed to treat this type of tumor …

Miltefosine (MLT) is an alkylphosphocholine with clinical success as an anticancer and
antiparasitic drug. Although the mechanism of action of MLT is highly debated, the …

Although many terpenes have shown antitumor, antibacterial, antifungal, and antiparasitic
activity, the mechanism of action is not well established. Electron paramagnetic resonance …

Leishmania parasites are the organisms responsible for one of the most important tropical
diseases, leishmaniasis. This neglected disease mainly affects populations in develo** or …

Miltefosine (MT) is a membrane-active alkylphospholipid licensed for the topical treatment of
breast cancer skin metastases and the oral treatment of leishmaniasis, although its …

In this study, we combined electron paramagnetic resonance (EPR) spectroscopy with an
analysis of biophysical cellular parameters to study the mechanisms underlying the in vitro …

Edelfosine (1-O-octadecyl-2-O-methyl-sn-glycero-phosphocholine) and miltefosine (
hexadecylphosphocholine) are synthetic alkylphospholipids (ALPs) that are reported to …

The sesquiterpene nerolidol is a membrane-active compound that has demonstrated
antitumor, antibacterial, antifungal and antiparasitic activities. In this study, we used electron …