This review article discusses the mechanisms of cardiomyogenesis in the adult heart. They
include the re-entry of cardiomyocytes into the cell cycle; dedifferentiation of pre-existing …

Cardiovascular diseases remain the major cause of death in the Western world. 1 Stem and
progenitor cell (SPC)–based therapies in animal models and human trials in recent years …

Background and Objectives Mesenchymal stem/progenitor cells (MSCs) are multipotent
progenitors that differentiate into such lineages as bone, fat, cartilage and stromal cells that …

Background—Therapeutic efficacy of bone marrow (BM) cell injection for treating ischemic
chronic heart failure has not been established. In addition, experimental data are lacking on …

The adult heart contains reservoirs of progenitor cells that express embryonic and stem cell-
related antigens. While these antigenically-purified cells are promising candidates for …

Human embryonic stem (HES) cells can give rise to cardiomyocytes in vitro. However,
whether undifferentiated HES cells also feature a myocardial regenerative capacity after in …

The seminal experiments showing that cells transplanted in infarcted hearts could effect
myocardial tissue repair have provided the proof of concept that cell therapy might be an …

Electrospun nanofibrous sheets get increasing attention in myocardial infarction (MI)
treatment due to their good cytocompatibility to deliver transplanted stem cells to infarcted …

Transforming growth factor-β1 (TGF-β1) was found to induce the myogenic differentiation of
bone marrow stem cells (BMSC). We investigated the morphological and …

In the past years, cardiovascular progenitor cells have been isolated from the human heart
and characterized. These cells can differentiate into cardiomyocytes, smooth muscle cells …